Alfimova M V, Golimbet V E, Barkhatova A N, Golubev S A, Korovaĭtseva G I
Zh Nevrol Psikhiatr Im S S Korsakova. 2009;109(12):50-4.
The association of 5-HTTLPR and Val66Met BDNF genotypes with symptoms of anxiety and depression related to stress caused by severe chronic psychiatric disease of a family member has been studied. Genotyping has been conducted in the group of 214 unaffected parents of patients with schizophrenia and 100 healthy age-matched controls. The diplotype Met*ss was associated with higher scores of depressive symptoms as assessed by MMPI in the group of parents but not in the control group. The most marked differences were seen in the subgroup of parents whose children had the greatest severity of symptoms. The results suggest that the interaction of 5-HTT and BDNF genes may moderate the association between objective and subjective burden of disease.
5-HTTLPR和Val66Met脑源性神经营养因子（BDNF）基因与因家庭成员严重慢性精神疾病所致压力相关的焦虑和抑郁症状之间的关联已得到研究。对214名精神分裂症患者的未患病父母及100名年龄匹配的健康对照者进行了基因分型。通过明尼苏达多相人格调查表（MMPI）评估，双倍型Met*ss与父母组中较高的抑郁症状评分相关，但在对照组中并非如此。在其子女症状最为严重的父母亚组中观察到最显著的差异。结果表明，5-羟色胺转运体（5-HTT）基因和BDNF基因的相互作用可能会调节疾病客观负担与主观负担之间的关联。
