Morozova O V, Tsyplakov D E, Krasnozhen V N
Vestn Otorinolaringol. 2009(5):16-9.
Samples of mucosal tissue from inferior nasal conchae for histological and immunological studies were collected during surgical intervention on 25 non-allergic patients with different clinical and morphological forms of chronic hypertrophic rhinitis. It was shown that the pathological process extends over all structures of conchal mucosa, namely, epithelium, lamina propria, and cavernous sinuses. However, proliferative activity of the epithelium may be spared, the structure of vascular endothelium, basement membranes of epithelium, glands and blood vessels remains either normal or only slightly affected, IgA synthesis persists, and immunocompetent cells (CD45 RO(+) T-lymphocytes, CD20(+) B-lymphocytes, and CD68(+) macrophages) retain functional activity. Taken together, these findings suggest high regenerative potential of nasal mucosa and preservation of mechanisms of local protection including cellular and humoral immunity despite the on-going pathological process. It implies the necessity of great caution during surgical interventions.
在对25例患有不同临床和形态学类型慢性肥厚性鼻炎的非过敏性患者进行手术干预期间，采集了下鼻甲黏膜组织样本用于组织学和免疫学研究。结果表明，病理过程累及鼻甲黏膜的所有结构，即上皮、固有层和海绵窦。然而，上皮的增殖活性可能未受影响，血管内皮结构、上皮、腺体和血管的基底膜保持正常或仅轻微受影响，IgA合成持续存在，免疫活性细胞（CD45 RO(+) T淋巴细胞、CD20(+) B淋巴细胞和CD68(+) 巨噬细胞）保留功能活性。综上所述，这些发现表明鼻黏膜具有很高的再生潜力，尽管病理过程持续存在，但包括细胞免疫和体液免疫在内的局部保护机制得以保留。这意味着在手术干预期间必须格外谨慎。
