在珠蛋白相互作用组中建立联系。

Getting connected in the globin interactome.

出版信息

Nat Genet. 2010 Jan;42(1):16-7. doi: 10.1038/ng0110-16.

PMID:20037614

Abstract

A new study provides compelling evidence that transcriptional regulation and three-dimensional genomic architecture are linked. The alpha- and beta-globin loci associate with hundreds of active genes across the genome at transcription factories in erythroid cells, and specialized Klf1-containing transcription factories mediate the association of Klf1-regulated genes.

摘要

一项新的研究提供了令人信服的证据，表明转录调控和三维基因组结构是相关的。在红细胞的转录工厂中，α-和β-珠蛋白基因座与基因组中数百个活跃基因相关联，并且含有特殊的 Klf1 的转录工厂介导 Klf1 调节基因的关联。