过氧化物酶体增殖物激活受体在放射性胃肠道毒性中的作用。
PPARs in Irradiation-Induced Gastrointestinal Toxicity.
机构信息
Institute for Radioprotection and Nuclear Safety, B.P. no.17, 92262 Fontenay aux Roses Cedex, France.
出版信息
PPAR Res. 2010;2010:528327. doi: 10.1155/2010/528327. Epub 2009 Nov 22.
Abstract
The use of radiation therapy to treat cancer inevitably involves exposure of normal tissues. Although the benefits of this treatment are well established, many patients experience distressing complications due to injury to normal tissue. These side effects are related to inflammatory processes, and they decrease therapeutic benefit by increasing the overall treatment time. Emerging evidence indicates that PPARs and their ligands are important in the modulation of immune and inflammatory reactions. This paper discusses the effects of abdominal irradiation on PPARs, their role and functions in irradiation toxicity, and the possibility of using their ligands for radioprotection.
摘要
放射治疗在治疗癌症时不可避免地会涉及正常组织的暴露。尽管这种治疗方法的益处已经得到充分证实，但许多患者由于正常组织损伤而经历痛苦的并发症。这些副作用与炎症过程有关，它们通过增加总体治疗时间来降低治疗效果。新出现的证据表明，过氧化物酶体增殖物激活受体及其配体在调节免疫和炎症反应中起着重要作用。本文讨论了腹部照射对过氧化物酶体增殖物激活受体的影响，它们在照射毒性中的作用和功能，以及使用它们的配体进行放射防护的可能性。
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