Széles Lajos, Töröcsik Dániel, Nagy László
Department of Biochemistry and Molecular Biology, Research Center for Molecular Medicine, University of Debrecen, Medical and Health Science Center, Life Science Building, Egyetem ter 1. Debrecen, H-4010 Hungary.
Biochim Biophys Acta. 2007 Aug;1771(8):1014-30. doi: 10.1016/j.bbalip.2007.02.005. Epub 2007 Feb 24.
The lipid activated transcription factor, PPARgamma appears to have multiple functions in the immune system. There are several cell types expressing the receptor, most prominently antigen presenting cells, such as macrophages and dendritic cells. The receptor's activation leads to primary transcriptional activation of many, mostly lipid metabolism-related genes. However, gene regulation also occurs on immunity and inflammation-related genes. Key questions are: in what way lipid metabolism and immune regulation are connected and how activation and/or repression of gene expression may modulate inflammatory and anti-inflammatory responses and in what way can these be utilized in therapy. Here we provide a cell type and disease centric review on the role of this lipid activated transcription factor in the various cells of the immune system it is expressed in, and in some major inflammatory diseases such as atherosclerosis, inflammatory bowel disease and rheumatoid arthritis.
脂质激活转录因子PPARγ似乎在免疫系统中具有多种功能。有几种细胞类型表达该受体，最显著的是抗原呈递细胞，如巨噬细胞和树突状细胞。该受体的激活导致许多主要与脂质代谢相关基因的初级转录激活。然而，基因调控也发生在与免疫和炎症相关的基因上。关键问题是：脂质代谢与免疫调节是如何联系的，基因表达的激活和/或抑制如何调节炎症和抗炎反应，以及这些如何在治疗中得到应用。在这里，我们以细胞类型和疾病为中心，综述了这种脂质激活转录因子在其表达的免疫系统各种细胞中以及在一些主要炎症性疾病如动脉粥样硬化、炎症性肠病和类风湿性关节炎中的作用。
