Department of General Surgery, Cumhuriyet University Medical School, Sivas, 58140, Turkey.
Surg Today. 2010;40(1):22-5. doi: 10.1007/s00595-008-4026-x. Epub 2009 Dec 29.
Graves' disease is the most frequent cause of hyperthyroidism. Although treatment with antithyroid drugs or radioactive iodine is effective, surgery remains the preferred treatment for many patients. We analyzed the results of 55 prospectively followed patients who underwent total thyroidectomy for Graves' disease.
Total thyroidectomy was performed by experienced endocrine surgeons in all 55 patients. We monitored the patients postoperatively for early and late complications.
There were 19 men, with a mean age of 42 years (range, 34-68 years) and 36 women, with a mean age of 38 years (range, 19-78 years). One patient suffered postoperative hemorrhage and subsequent wound infection, two patients had transient recurrent laryngeal nerve palsy, and 24 patients had transient hypocalcemia. The mean follow-up time was 4 years (range, 10 months to 6 years). Recurrence of hyperthyroidism was not reported in this period.
Removal of all thyroid tissue offers the best chance of preventing recurrent hyperthyroidism. Total thyroidectomy is the most effective surgery for achieving the goal of treatment of Graves' disease to ensure that hyperthyroidism will not recur.
Graves 病是最常见的甲状腺功能亢进症病因。尽管抗甲状腺药物或放射性碘治疗有效，但手术仍然是许多患者的首选治疗方法。我们分析了 55 例接受 Graves 病全甲状腺切除术的前瞻性随访患者的结果。
55 例患者均由经验丰富的内分泌外科医生行全甲状腺切除术。我们术后监测患者的早期和晚期并发症。
19 例为男性，平均年龄 42 岁（范围 34-68 岁），36 例为女性，平均年龄 38 岁（范围 19-78 岁）。1 例患者术后发生出血和随后的伤口感染，2 例患者发生短暂性喉返神经麻痹，24 例患者发生短暂性低钙血症。平均随访时间为 4 年（范围 10 个月至 6 年）。在此期间未报告甲亢复发。
切除所有甲状腺组织提供了预防甲亢复发的最佳机会。全甲状腺切除术是实现 Graves 病治疗目标的最有效手术，可确保甲亢不再复发。
