Gürsel Gül, Aydoğdu Müge
Department of Chest Diseases, Faculty of Medicine, Gazi University, Ankara, Turkey.
Tuberk Toraks. 2009;57(4):453-65.
Mechanically ventilated patients interact with ventilator functions at different levels such as triggering of the ventilator, pressurization and cycling from inspiration to expiration. Patient ventilator asynchrony in any one of these phase results in fighting with ventilator, increase in work of breathing and respiratory muscle fatigue. Patient ventilator dyssynchrony occurs when gas delivery from the ventilator does not match with the neural output of the respiratory center. The clinical findings of patient-ventilator asynchrony are; use of accessory respiratory muscle, tachypnea, tachycardia, active expiration, diaphoresis and observation of asynchrony between patient respiratory effort and the ventilator waveforms. Among the patients with dynamic hyperinflation such as chronic obstructive pulmonary disease the most frequent causes of patient-ventilator asynchrony are trigger and expiratory asynchronies. In acute respiratory distress syndrome patient-ventilator asynchrony may develop due to problems in triggering or asynchrony in flow and inspiration-expiration cycle. Patient-ventilator interaction during noninvasive mechanical ventilation may be affected by the type of masks used, ventilator types, ventilation modes and parameters, humidification and sedation. Among the different patient groups it is important to know causes and solutions of patient-ventilator asynchrony problems. By this way patient will adapt ventilator and then dyspnea, ineffective respiratory effort and work of breathing may decrease subsequently.
机械通气患者在不同层面与呼吸机功能相互作用,如呼吸机触发、增压以及从吸气到呼气的切换。这些阶段中任何一个阶段出现患者-呼吸机不同步,都会导致与呼吸机对抗、呼吸功增加以及呼吸肌疲劳。当呼吸机送气与呼吸中枢的神经输出不匹配时,就会发生患者-呼吸机不同步。患者-呼吸机不同步的临床表现包括:使用辅助呼吸肌、呼吸急促、心动过速、主动呼气、出汗以及观察到患者呼吸努力与呼吸机波形之间的不同步。在慢性阻塞性肺疾病等动态肺过度充气的患者中,患者-呼吸机不同步最常见的原因是触发和呼气不同步。在急性呼吸窘迫综合征中,患者-呼吸机不同步可能由于触发问题或流量及吸气-呼气周期不同步而出现。无创机械通气期间患者-呼吸机的相互作用可能会受到所用面罩类型、呼吸机类型、通气模式和参数、湿化及镇静的影响。在不同患者群体中,了解患者-呼吸机不同步问题的原因和解决方法很重要。通过这种方式,患者将适应呼吸机,随后呼吸困难、无效呼吸努力和呼吸功可能会降低。