Endothelial and vascular muscle PPARgamma in arterial pressure regulation: lessons from genetic interference and deficiency.
作者信息
Sigmund Curt D
机构信息
Department of Internal Medicine, Center on Functional Genomics of Hypertension, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, Iowa 52242, USA.
出版信息
Hypertension. 2010 Feb;55(2):437-44. doi: 10.1161/HYPERTENSIONAHA.109.144170. Epub 2009 Dec 28.
Abstract
摘要
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Next generation multifunctional angiotensin receptor blockers.下一代多功能血管紧张素受体阻滞剂。
Hypertens Res. 2009 Oct;32(10):826-34. doi: 10.1038/hr.2009.135. Epub 2009 Aug 28.
2
Chronic treatment with losartan results in sufficient serum levels of the metabolite EXP3179 for PPARgamma activation.氯沙坦的长期治疗可使代谢产物EXP3179的血清水平达到足以激活PPARγ的程度。
Hypertension. 2009 Oct;54(4):738-43. doi: 10.1161/HYPERTENSIONAHA.109.132886. Epub 2009 Aug 17.
3
Disruption of endothelial peroxisome proliferator-activated receptor-gamma reduces vascular nitric oxide production.内皮过氧化物酶体增殖物激活受体γ的破坏会降低血管一氧化氮的生成。
Am J Physiol Heart Circ Physiol. 2009 Nov;297(5):H1647-54. doi: 10.1152/ajpheart.00148.2009. Epub 2009 Aug 7.
4
Defective peroxisomal proliferators activated receptor gamma activity due to dominant-negative mutation synergizes with hypertension to accelerate cardiac fibrosis in mice.由于显性负性突变导致的过氧化物酶体增殖物激活受体γ活性缺陷与高血压协同作用，加速小鼠心脏纤维化。
Eur J Heart Fail. 2009 Jun;11(6):533-41. doi: 10.1093/eurjhf/hfp048. Epub 2009 Apr 24.
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Vascular smooth muscle cell-selective peroxisome proliferator-activated receptor-gamma deletion leads to hypotension.血管平滑肌细胞选择性过氧化物酶体增殖物激活受体γ缺失导致低血压。
Circulation. 2009 Apr 28;119(16):2161-9. doi: 10.1161/CIRCULATIONAHA.108.815803. Epub 2009 Apr 13.
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Dominant-negative loss of PPARgamma function enhances smooth muscle cell proliferation, migration, and vascular remodeling.PPARγ功能的显性负性缺失增强了平滑肌细胞的增殖、迁移和血管重塑。
Arterioscler Thromb Vasc Biol. 2009 Apr;29(4):465-71. doi: 10.1161/ATVBAHA.109.184234. Epub 2009 Jan 29.
7
Distinct functions of vascular endothelial and smooth muscle PPARgamma in regulation of blood pressure and vascular tone.血管内皮和血管平滑肌中过氧化物酶体增殖物激活受体γ在血压和血管张力调节中的不同功能。
Toxicol Pathol. 2009 Jan;37(1):21-7. doi: 10.1177/0192623308328545. Epub 2008 Dec 15.
8
PPARgamma in the endothelium regulates metabolic responses to high-fat diet in mice.内皮细胞中的过氧化物酶体增殖物激活受体γ调节小鼠对高脂饮食的代谢反应。
J Clin Invest. 2009 Jan;119(1):110-24. doi: 10.1172/JCI36233. Epub 2008 Dec 8.
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Vascular PPARgamma controls circadian variation in blood pressure and heart rate through Bmal1.血管中的过氧化物酶体增殖物激活受体γ（PPARγ）通过Bmal1控制血压和心率的昼夜变化。
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Bcr kinase activation by angiotensin II inhibits peroxisome-proliferator-activated receptor gamma transcriptional activity in vascular smooth muscle cells.血管紧张素 II 激活 Bcr 激酶可抑制血管平滑肌细胞中过氧化物酶体增殖物激活受体γ的转录活性。
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