Easley R B, Rodbard D
Clin Pharmacol Ther. 1977 Dec;22(6):881-7. doi: 10.1002/cpt1977226881.
Sphygmo-Recording is a simple, noninvasive technique for analysis of pulse wave contour and timing which has been used to evaluate the change in cardiac dynamics during isoproterenol infusion. The QKd interval, i.e., the time interval between the onset of the QRS complex and the onset of the Korotkoff sound at the brachial artery when the sphygomomanometer cuff is at diastolic pressure, is normally 205 +/- 15 msec. Continuous intravenous infusion of isoproterenol at 0.01, 0.02, and 0.03 microgram/kg/min into 12 euthyroid normotensive adult volunteers for 10-min intervals resulted in decreases of 55, 79, and 89 msec in QKd and increases of heart rate of 14, 27, and 43 beats/min, respectively. The corresponding changes in dP/dt, i.e., slope of the pulse wave upstroke at the brachial artery determined noninvasively from the same records, were 0.65, 1.47, and 2.26 mm Hg/msec. These results confirm previous studies which indicate that the chronotropic response of normal subjects to isoproterenol infusion is comparable to that previously reported in patients with the putative "hyperdynamic beta-adrenergic state."
脉搏记录是一种简单的非侵入性技术，用于分析脉搏波的形态和时间，已被用于评估异丙肾上腺素输注期间心脏动力学的变化。QKd间期，即当血压计袖带处于舒张压时，QRS波群起始点与肱动脉处柯氏音起始点之间的时间间隔，正常为205±15毫秒。对12名甲状腺功能正常、血压正常的成年志愿者以0.01、0.02和0.03微克/千克/分钟的速度连续静脉输注异丙肾上腺素，每次输注10分钟，结果QKd分别缩短了55、79和89毫秒，心率分别增加了14、27和43次/分钟。从相同记录中无创测定的肱动脉脉搏波上升斜率dP/dt的相应变化分别为0.65、1.47和2.26毫米汞柱/毫秒。这些结果证实了先前的研究，表明正常受试者对异丙肾上腺素输注的变时反应与先前报道的假定“高动力β-肾上腺素能状态”患者的反应相当。
