Fallowfield M E, Curley R K, Cook M G
Department of Histopathology, St George's Hospital, London, U.K.
Br J Dermatol. 1991 Feb;124(2):130-4. doi: 10.1111/j.1365-2133.1991.tb00421.x.
Basal melanocytes were counted and atypia assessed on an arbitrary scale in punch biopsies from the sun-exposed extensor aspect of the forearm of normal skin and from the covered skin of the buttock of patients with pigmented naevi and control subjects. The difference in melanocyte counts and in the presence of atypia between sun-exposed and covered skin was statistically highly significant. The only other difference was between melanocyte counts in covered skin from those with multiple atypical naevi and all other groups; the counts in the former were greater than those in the latter. No further difference was attributable to sun exposure, skin type or diagnostic group. Some degree of melanocyte atypia was seen in approximately half of the biopsies of sun-exposed skin, but atypia was seen in only six of 84 biopsies of covered skin. In each case atypia was present in the corresponding forearm biopsy and all six subjects had pigmented lesions (four with melanoma and two with multiple atypical naevi). It seems possible that while increased melanocyte counts in covered skin could correlate with the presence of atypical naevi, atypia of covered epidermal melanocytes could possibly relate to melanoma risk.
对正常皮肤前臂日光暴露的伸侧以及色素痣患者和对照受试者臀部隐蔽皮肤的钻孔活检标本进行基底黑素细胞计数，并采用任意量表评估细胞异型性。日光暴露皮肤和隐蔽皮肤之间黑素细胞计数及细胞异型性的差异具有高度统计学意义。唯一的其他差异存在于有多个非典型痣者的隐蔽皮肤与所有其他组的黑素细胞计数之间；前者的计数高于后者。日光暴露、皮肤类型或诊断组之间未发现进一步差异。日光暴露皮肤的活检标本中约半数可见一定程度的黑素细胞异型性，但84例隐蔽皮肤活检标本中仅6例可见异型性。在每种情况下，相应的前臂活检标本均存在异型性，且所有6名受试者均有色素沉着病变（4例为黑色素瘤，2例为多个非典型痣）。似乎有可能，虽然隐蔽皮肤中黑素细胞计数增加可能与非典型痣的存在相关，但隐蔽表皮黑素细胞的异型性可能与黑色素瘤风险有关。
