County of San Diego Medical Examiner's Office, San Diego, California 92123, USA.
J Anal Toxicol. 2009 Nov-Dec;33(9):615-9. doi: 10.1093/jat/33.9.615.
There has been an increased awareness of illicit opiate abusers using the narcotic oxymorphone (Opana) by inhalation. Many laboratory screening techniques currently in use cannot detect oxymorphone in blood or urine. Consequently, biological specimens containing low to moderate concentrations of oxymorphone will likely go undetected. The circumstances, pathology findings, and toxicology results of two fatalities involving oxymorphone are presented. An opiate confirmation gas chromatography-mass spectrometry (GC-MS) procedure, described in detail was able to detected, confirm, and quantify oxymorphone in both subjects. The blood concentrations were 0.05 mg/L (50 microg/L) and 0.12 mg/L (120 microg/L).
人们越来越意识到，非法阿片类药物滥用者通过吸入的方式来使用麻醉性阿片类药物羟吗啡酮（Opana）。目前许多实验室常用的筛选技术无法检测血液或尿液中的羟吗啡酮。因此，含有低至中等浓度羟吗啡酮的生物样本可能会被漏检。本文介绍了涉及羟吗啡酮的两例死亡事件的情况、病理发现和毒理学结果。详细描述的阿片类药物确证气相色谱-质谱联用（GC-MS）程序能够检测、确认并定量分析两个检材中的羟吗啡酮。血液浓度分别为 0.05 毫克/升（50 微克/升）和 0.12 毫克/升（120 微克/升）。
