Rohrig Timothy P, Miller Samuel A, Baird Tyson R
Regional Forensic Science Center, 1109 N. Minneapolis, Wichita, KS 67214,USA.
J Anal Toxicol. 2018 Jan 1;42(1):e12-e14. doi: 10.1093/jat/bkx081.
U-47700 was developed by the Upjohn Co. in the 1970s as part of their search for a selective μ-opioid agonist with similar potency as morphine. U-47700 has re-emerged recently in the illicit drug market and is easily and cheaply obtained via the internet as well as on the street, many times falsely sold as another drug. Several fatalities from U-47700 have been reported in scientific literature, often in combination with other intoxicants. This case report describes the first death in south-central Kansas resulting solely from U-47700 intoxication: a 26-year-old white male found dead in his bedroom with apparent drug paraphernalia. Autopsy findings were consistent with opioid overdose, but toxicological examination, utilizing immunoassay and instrumental techniques, was negative for opioids. U-47700 was detected in a comprehensive alkaloid screen by GC/MS and GC-NPD, and quantitation was performed using GC-NPD on a variety of specimens to provide a full tissue distribution. Quantitation of U-47700 in this individual revealed the following: heart blood 0.26 mg/L, femoral blood 0.40 mg/L, vitreous fluid 0.09 mg/L, brain 0.38 mg/kg, liver 0.28 mg/kg and urine 4.6 mg/L.
U-47700由Upjohn公司于20世纪70年代研发，是他们寻找一种与吗啡效力相似的选择性μ阿片受体激动剂工作的一部分。U-47700最近在非法毒品市场再度出现，通过互联网以及街头很容易且廉价地就能获得，很多时候被误当作另一种毒品出售。科学文献中已报道了几起因U-47700导致的死亡案例，通常是与其他 intoxicants 混合使用。本病例报告描述了堪萨斯州中南部首例仅因U-47700中毒导致的死亡：一名26岁白人男性被发现死在其卧室，身边有明显的吸毒用具。尸检结果与阿片类药物过量相符，但使用免疫分析和仪器技术进行的毒理学检查对阿片类药物呈阴性。通过气相色谱/质谱联用仪（GC/MS）和气相色谱 - 氮磷检测器（GC-NPD）在全面的生物碱筛查中检测到了U-47700，并使用GC-NPD对各种标本进行定量分析以提供完整的组织分布情况。对该个体体内U-47700的定量分析结果如下：心脏血液中为0.26毫克/升，股静脉血液中为0.40毫克/升，玻璃体液中为0.09毫克/升，大脑中为0.38毫克/千克，肝脏中为0.28毫克/千克，尿液中为4.6毫克/升。
