Rumana M, Kirmani A, Khursheed N, Besina S, Khalil M
Departments of Pathology, SKIMS, Kashmir, India.
Clin Neuropathol. 2010 Jan-Feb;29(1):26-31. doi: 10.5414/npp29026.
Lymphocytic hypophysitis (LYH) is a rare autoimmune inflammatory disorder of the pituitary gland usually affecting young women, often in pregnancy or post partum period. It is rare in non-pregnant females and in men. Patients present with symptoms of an expanding pituitary mass and/or varying degrees of pituitary dysfunction. We, hereby report a case of lymphocytic hypophysitis in a 28-year-old non-pregnant female who presented with clinical and radiological features of a pituitary tumor with normal pituitary hormones which on histopathological examination revealed features of lymphocytic hypophysitis. The case is presented here for its rarity and its unique presentation as an expanding pituitary mass with normal pituitary function. Peculiar clinical, radiological and histopathological features of this uncommon entity are discussed.
淋巴细胞性垂体炎(LYH)是一种罕见的垂体自身免疫性炎症性疾病,通常影响年轻女性,常在孕期或产后发病。在非妊娠女性和男性中较为罕见。患者表现为垂体肿块增大的症状和/或不同程度的垂体功能障碍。在此,我们报告一例28岁非妊娠女性的淋巴细胞性垂体炎病例,该患者具有垂体肿瘤的临床和影像学特征,但垂体激素水平正常,组织病理学检查显示为淋巴细胞性垂体炎。因其罕见性以及作为垂体肿块增大但垂体功能正常的独特表现,现将该病例呈现于此。本文讨论了这一罕见疾病独特的临床、影像学和组织病理学特征。