Hartmann I, Tallen G, Gräf K J, Unterberg A, Lanksch W R, Stoltenburg-Didinger G
Institute of Neuropathology, Universitätsklinikum Benjamin Franklin, Freie Universität Berlin, Germany.
Clin Neuropathol. 1996 Jul-Aug;15(4):234-9.
Lymphocytic adenohypophysitis can cause pituitary expansion and hypopituitarism closely mimicking the features of a pituitary adenoma. In contrast to pituitary adenoma, lymphocytic adenohypophysitis occurs almost exclusively in young women in relation to pregnancy. We report a case of a 43-year-old nonpregnant nullipara who exhibited an intrasellar mass with diffuse homogeneous contrast enhancement on magnetic resonance imaging scanning. Serum hormone analyses revealed secondary hypoadrenalism, hypothyroidism, and hypogonadism. The patient underwent surgery for a presumed nonsecreting pituitary adenoma. Histopathological examination showed extensive infiltration of the anterior pituitary gland by chronic inflammatory cells. The immunohistochemical pattern of the inflammatory cells indicated the chronic and putatively autoimmune nature of the disease.
淋巴细胞性垂体炎可导致垂体增大和垂体功能减退，与垂体腺瘤的特征极为相似。与垂体腺瘤不同，淋巴细胞性垂体炎几乎仅发生于妊娠相关的年轻女性。我们报告一例43岁未孕未育女性，磁共振成像扫描显示鞍内肿块，造影剂弥漫均匀强化。血清激素分析显示继发性肾上腺功能减退、甲状腺功能减退和性腺功能减退。该患者因疑似无分泌功能的垂体腺瘤接受了手术。组织病理学检查显示前叶垂体有慢性炎症细胞广泛浸润。炎症细胞的免疫组化模式表明该疾病具有慢性且可能为自身免疫性的性质。
