Lakhal K, Pallancher S, Mathieu-Daude J-C, Harry P, Capdevila X
Réanimation Polyvalente, Département d'Anesthésie-Réanimation A, Hôpital Lapeyronie, Centre Hospitalier Universitaire, 34000 Montpellier, France.
Int J Clin Pharmacol Ther. 2010 Jan;48(1):79-83. doi: 10.5414/cpp48079.
Bromazepam intoxication is very common but surprisingly rarely reported.
We describe the case of a 73-year-old woman who suffered from a prolonged coma after acute self poisoning with bromazepam (serum concentration of 2,000 ng/ml at admission, 2 - 10 hours after ingestion of up to 180 mg) and zolpidem (900 ng/ml at admission). Only the former lasted at toxic concentrations. Recovery of consciousness allowed extubation on Day 16. Repeat-dose activated charcoal (25 g every 6 h from Day 14 to 16) resulted in minimal effects on bromazepam grossly estimated kinetics.
Despite its relatively low theoretic half-life, bromazepam may induce a prolonged life-threatening coma, even in the absence of renal or hepatic failure.
溴西泮中毒很常见，但令人惊讶的是报道很少。
我们描述了一名73岁女性的病例，她在急性自服溴西泮（入院时血清浓度为2000纳克/毫升，摄入高达180毫克后2至10小时）和唑吡坦（入院时900纳克/毫升）后陷入长时间昏迷。只有前者在中毒浓度下持续存在。意识恢复后于第16天拔管。重复剂量活性炭（从第14天到16天每6小时25克）对溴西泮总体估计动力学影响极小。
尽管溴西泮理论半衰期相对较短，但即使在没有肾衰竭或肝功能衰竭的情况下，也可能导致危及生命的长时间昏迷。
