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原位肝移植中的输血实践。

Transfusion practice in orthotopic liver transplantation.

作者信息

Devi Allanki Surekha

机构信息

Department of Transfusion Medicine, Global Hospitals, Hyderabad - 500 004, India.

出版信息

Indian J Crit Care Med. 2009 Jul-Sep;13(3):120-8. doi: 10.4103/0972-5229.58536.

DOI:10.4103/0972-5229.58536
PMID:20040808
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2823092/
Abstract

Liver transplant procedures require the most blood components, despite the fact that blood use in liver transplantation has declined dramatically over the last decade. Liver transplant recipients present unique challenges, not only in terms of blood supply, but also requirements for specialized blood components, serologic problems, and immunologic effects of transfusion on both the allograft and the recipient. The cause of intraoperative blood loss in liver transplantation is multifactorial, due to both technical factors and poor coagulation control. This procedure carries the risk of massive blood loss, which requires massive transfusions and is associated with postoperative infections, reduced graft survival, multi-organ dysfunction, and higher risk of mortality. Efforts to reduce intraoperative bleeding leading to limitation of blood transfusions are desirable to improve results and also to control costs. Method of literature search: The name of topic is typed and searched in Google search. The name of topic is typed and searched in PubMed search. Related articles were also searched. Some standard books in Transfusion Medicine were also referred.

摘要

肝移植手术需要最多的血液成分,尽管在过去十年中肝移植中的用血情况已大幅下降。肝移植受者面临着独特的挑战,不仅在血液供应方面,而且在特殊血液成分的需求、血清学问题以及输血对同种异体移植物和受者的免疫影响方面。肝移植术中失血的原因是多因素的,既包括技术因素,也包括凝血控制不佳。该手术存在大量失血的风险,这需要大量输血,并且与术后感染、移植物存活率降低、多器官功能障碍以及更高的死亡风险相关。减少术中出血以限制输血的努力对于改善结果以及控制成本都是可取的。文献检索方法:在谷歌搜索中输入并搜索主题名称。在PubMed搜索中输入并搜索主题名称。还搜索了相关文章。也参考了输血医学方面的一些标准书籍。

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1
Transfusion practice in orthotopic liver transplantation.原位肝移植中的输血实践。
Indian J Crit Care Med. 2009 Jul-Sep;13(3):120-8. doi: 10.4103/0972-5229.58536.
2
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3
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引用本文的文献

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2
Ultra-massive fluid transfusion in adult liver transplant recipients: A single center observational study.成年肝移植受者的超大剂量液体输注:一项单中心观察性研究。
PLoS One. 2025 Jun 17;20(6):e0325829. doi: 10.1371/journal.pone.0325829. eCollection 2025.
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Quality Improvement in Transfusion Practice of Orthotopic Liver Transplantation Reduces Blood Utilization, Length of Hospital Stay, and Cost.原位肝移植中输血实践的质量改进可减少血液使用量、住院时间和成本。
Am J Clin Pathol. 2019 Mar 1;151(4):395-402. doi: 10.1093/ajcp/aqy154.
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Fibrinolytic System Changes in Liver Surgery: A Pilot Observational Study.肝脏手术中纤溶系统的变化:一项初步观察性研究。
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Blood transfusion practices in liver transplantation.肝移植中的输血实践。
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本文引用的文献

1
Transfusion-related acute lung injury surveillance (2003-2005) and the potential impact of the selective use of plasma from male donors in the American Red Cross.输血相关急性肺损伤监测(2003 - 2005年)以及美国红十字会选择性使用男性献血者血浆的潜在影响。
Transfusion. 2007 Apr;47(4):599-607. doi: 10.1111/j.1537-2995.2007.01102.x.
2
Comparison of the effects of aprotinin and tranexamic acid on blood loss and red blood cell transfusion requirements during the late stages of liver transplantation.抑肽酶与氨甲环酸对肝移植后期失血及红细胞输注需求影响的比较
Transfusion. 2006 Apr;46(4):595-605. doi: 10.1111/j.1537-2995.2006.00770.x.
3
Comparison of histidine-tryptophan-ketoglutarate solution (HTK) and University of Wisconsin solution (UW) in adult liver transplantation.成人肝移植中组氨酸-色氨酸-酮戊二酸溶液(HTK)与威斯康星大学溶液(UW)的比较。
Liver Transpl. 2006 Feb;12(2):226-30. doi: 10.1002/lt.20552.
4
Effect of low central venous pressure and phlebotomy on blood product transfusion requirements during liver transplantations.低中心静脉压和放血对肝移植期间血液制品输注需求的影响。
Liver Transpl. 2006 Jan;12(1):117-23. doi: 10.1002/lt.20559.
5
Transfusion free surgery: single institution experience of 27 consecutive liver transplants in Jehovah's Witnesses.无输血手术:一家机构对27例耶和华见证人教派信徒连续进行肝移植手术的经验
J Am Coll Surg. 2005 Sep;201(3):412-7. doi: 10.1016/j.jamcollsurg.2005.04.006.
6
Efficacy and safety of repeated perioperative doses of recombinant factor VIIa in liver transplantation.围手术期重复剂量重组凝血因子VIIa在肝移植中的疗效和安全性
Liver Transpl. 2005 Aug;11(8):973-9. doi: 10.1002/lt.20470.
7
Liver transplantation in Jehovah's witnesses.耶和华见证人的肝移植
Transpl Int. 2005 Aug;18(8):929-36. doi: 10.1111/j.1432-2277.2005.00160.x.
8
Intraoperative blood loss during living donor liver transplantation: an analysis of 635 recipients at a single center.活体肝移植术中失血情况:单中心635例受者分析
Transfusion. 2005 Jun;45(6):879-84. doi: 10.1111/j.1537-2995.2005.04330.x.
9
Intraoperative blood transfusion requirement is the main determinant of early surgical re-intervention after orthotopic liver transplantation.术中输血需求是原位肝移植术后早期手术再次干预的主要决定因素。
Transpl Int. 2005 Jan;17(11):673-9. doi: 10.1007/s00147-004-0793-5. Epub 2004 Dec 10.
10
Antifibrinolytics in orthotopic liver transplantation: current status and controversies.原位肝移植中的抗纤溶药物:现状与争议
Liver Transpl. 2005 Jan;11(1):10-8. doi: 10.1002/lt.20275.