Changizi V, Kheradmand A Arab, Oghabian M A
Radiology and Radiotherapy Technology Department, Allied Medical Sciences School, Medical Sciences/University of Tehran, Tehran, Iran.
J Med Phys. 2008 Jan;33(1):19-23. doi: 10.4103/0971-6203.39420.
Small-angle X-ray scattering (SAXS) is an X-ray diffraction-based technique where a narrow collimated beam of X-rays is focused onto a sample and the scattered X-rays recorded by a detector. The pattern of the scattered X-rays carries information on the molecular structure of the material. As breast cancer is the most widespread cancer in women and differentiation among its tumors is important, this project compared the results of coherent X-ray scattering measurements obtained from benign and malignant breast tissues. The energy-dispersive method with a setup including X-ray tube, primary collimator, sample holder, secondary collimator and high-purity germanium (HpGe) detector was used. One hundred thirty-one breast-tissue samples, including normal, fibrocystic changes and carcinoma, were studied at the 6 degrees scattering angle. Diffraction profiles (corrected scattered intensity versus momentum transfer) of normal, fibrocystic changes and carcinoma were obtained. These profiles showed a few peak positions for adipose (1.15 +/- 0.06 nm(-1)), mixed normal (1.15 +/- 0.06 nm(-1) and 1.4 +/- 0.04 nm(-1)), fibrocystic changes (1.46 +/- 0.05 nm(-1) and 1.74 +/- 0.04 nm(-1)) and carcinoma (1.55 +/- 0.04 nm(-1), 1.73 +/- 0.06 nm(-1), 1.85 +/- 0.05 nm(-1)). We were able to differentiate between normal, fibrocystic changes (benign) and carcinoma (malignant) breast tissues by SAXS. However, we were unable to differentiate between different types of carcinoma.
小角X射线散射（SAXS）是一种基于X射线衍射的技术，其中一束狭窄的准直X射线束聚焦到样品上，散射的X射线由探测器记录。散射X射线的图案携带有关材料分子结构的信息。由于乳腺癌是女性中最常见的癌症，其肿瘤之间的分化很重要，因此该项目比较了从良性和恶性乳腺组织获得的相干X射线散射测量结果。使用了一种能量色散方法，其设置包括X射线管、初级准直器、样品架、次级准直器和高纯度锗（HpGe）探测器。在6度散射角下研究了131个乳腺组织样本，包括正常、纤维囊性改变和癌组织。获得了正常、纤维囊性改变和癌组织的衍射图谱（校正后的散射强度与动量转移关系）。这些图谱显示了脂肪组织（1.15±0.06 nm-1）、混合正常组织（1.15±0.06 nm-1和1.4±0.04 nm-1）、纤维囊性改变组织（1.46±0.05 nm-1和1.74±0.04 nm-1）和癌组织（1.55±0.04 nm-1、1.73±0.06 nm-1、1.85±0.05 nm-1）的几个峰位置。我们能够通过SAXS区分正常、纤维囊性改变（良性）和癌（恶性）乳腺组织。然而，我们无法区分不同类型的癌。
