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The inflammasomes.

作者信息

Lamkanfi Mohamed, Dixit Vishva M

机构信息

Department of Physiological Chemistry, Genentech, South San Francisco, California, USA.

出版信息

PLoS Pathog. 2009 Dec;5(12):e1000510. doi: 10.1371/journal.ppat.1000510. Epub 2009 Dec 24.

DOI:10.1371/journal.ppat.1000510
PMID:20041168
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2791419/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/01d3/2791419/24bacd7bc0a4/ppat.1000510.g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/01d3/2791419/24bacd7bc0a4/ppat.1000510.g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/01d3/2791419/24bacd7bc0a4/ppat.1000510.g001.jpg

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An orthogonal proteomic-genomic screen identifies AIM2 as a cytoplasmic DNA sensor for the inflammasome.一项正交蛋白质组学-基因组学筛选确定AIM2为炎性小体的细胞质DNA传感器。
Nat Immunol. 2009 Mar;10(3):266-72. doi: 10.1038/ni.1702. Epub 2009 Jan 21.
3
AIM2 activates the inflammasome and cell death in response to cytoplasmic DNA.AIM2响应细胞质DNA激活炎性小体和细胞死亡。
脑脓毒性栓子：诱导性肌坏死的一种独特并发症。
J Investig Med High Impact Case Rep. 2025 Jan-Dec;13:23247096251342027. doi: 10.1177/23247096251342027. Epub 2025 May 31.
4
P62 inhibits IL-1β release during Typhimurium infection of macrophages.P62在鼠伤寒沙门氏菌感染巨噬细胞期间抑制白细胞介素-1β的释放。
Front Cell Infect Microbiol. 2025 Apr 10;15:1495567. doi: 10.3389/fcimb.2025.1495567. eCollection 2025.
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NLRP3 Inflammasome Triggers Inflammation of Obstructive Sleep Apnea.NLRP3炎性小体引发阻塞性睡眠呼吸暂停炎症。
Curr Mol Med. 2025;25(5):522-536. doi: 10.2174/0115665240294605240426123650.
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