炎性小体 - Suppr | 超能文献

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The inflammasomes.

作者信息

Lamkanfi Mohamed, Dixit Vishva M

机构信息

Department of Physiological Chemistry, Genentech, South San Francisco, California, USA.

出版信息

PLoS Pathog. 2009 Dec;5(12):e1000510. doi: 10.1371/journal.ppat.1000510. Epub 2009 Dec 24.

DOI:10.1371/journal.ppat.1000510

PMID:20041168

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2791419/

Abstract

摘要

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/01d3/2791419/24bacd7bc0a4/ppat.1000510.g001.jpg

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本文引用的文献

Towards an understanding of the adjuvant action of aluminium.关于对铝的佐剂作用的理解。

Nat Rev Immunol. 2009 Apr;9(4):287-93. doi: 10.1038/nri2510.

An orthogonal proteomic-genomic screen identifies AIM2 as a cytoplasmic DNA sensor for the inflammasome.一项正交蛋白质组学-基因组学筛选确定AIM2为炎性小体的细胞质DNA传感器。

Nat Immunol. 2009 Mar;10(3):266-72. doi: 10.1038/ni.1702. Epub 2009 Jan 21.

AIM2 activates the inflammasome and cell death in response to cytoplasmic DNA.AIM2响应细胞质DNA激活炎性小体和细胞死亡。

Nature. 2009 Mar 26;458(7237):509-13. doi: 10.1038/nature07710. Epub 2009 Jan 21.

AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC.AIM2可识别胞质双链DNA，并与ASC形成激活半胱天冬酶-1的炎性小体。

Nature. 2009 Mar 26;458(7237):514-8. doi: 10.1038/nature07725. Epub 2009 Jan 21.

HIN-200 proteins regulate caspase activation in response to foreign cytoplasmic DNA.HIN-200蛋白响应外源细胞质DNA调节半胱天冬酶激活。

Science. 2009 Feb 20;323(5917):1057-60. doi: 10.1126/science.1169841. Epub 2009 Jan 8.

Differential requirement for the activation of the inflammasome for processing and release of IL-1beta in monocytes and macrophages.单核细胞和巨噬细胞中炎性小体激活对白细胞介素-1β加工和释放的不同需求。

Blood. 2009 Mar 5;113(10):2324-35. doi: 10.1182/blood-2008-03-146720. Epub 2008 Dec 22.

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J Immunol. 2008 Sep 15;181(6):3755-9. doi: 10.4049/jimmunol.181.6.3755.

The Nlrp3 inflammasome is critical for aluminium hydroxide-mediated IL-1beta secretion but dispensable for adjuvant activity.Nlrp3炎性小体对于氢氧化铝介导的白细胞介素-1β分泌至关重要，但对于佐剂活性却是可有可无的。

Eur J Immunol. 2008 Aug;38(8):2085-9. doi: 10.1002/eji.200838549.

Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization.二氧化硅晶体和铝盐通过吞噬体不稳定激活NALP3炎性小体。

Nat Immunol. 2008 Aug;9(8):847-56. doi: 10.1038/ni.1631. Epub 2008 Jul 11.

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