透明质酸（HA）精子选择的效率。
Efficiency of hyaluronic acid (HA) sperm selection.
机构信息
Reproductive Medicine Unit-GynePro Medical Centers, GynePro Medical, Via T. Cremona, 8-40137, Bologna, Italy.
出版信息
J Assist Reprod Genet. 2010 Jan;27(1):13-6. doi: 10.1007/s10815-009-9380-0. Epub 2009 Dec 30.
Abstract
PURPOSE
Hyaluronic Acid (HA) has a role as "physiologic selector" for spermatozoa prior to intracytoplasmic sperm injection (ICSI). The objective of this study is to analyze the results achievable by the introduction of a routine HA-ICSI programme.
METHODS
We retrospectively observed 293 couples treated with HA-ICSI versus 86 couples treated with conventional PVP-ICSI (historical control group). ICSI was performed on a limited number of oocytes per patient (1-3) according to Italian IVF law at the time of the study. Main outcome measures observed were: fertilization, embryo quality, implantation and pregnancy.
RESULTS
This study showed that Injection of HA-bound spermatozoa (HA-ICSI) significantly improves embryo quality and implantation.
CONCLUSIONS
If wider multi-center randomized studies will confirm these beneficial effects on ICSI outcome, HA could be considered as a routine choice for "physiologic" sperm selection prior to ICSI.
摘要
目的
透明质酸（HA）在胞质内单精子注射（ICSI）之前作为精子的“生理选择器”发挥作用。本研究的目的是分析引入常规 HA-ICSI 方案可实现的结果。
方法
我们回顾性观察了 293 对接受 HA-ICSI 治疗的夫妇与 86 对接受传统 PVP-ICSI（历史对照组）治疗的夫妇。根据当时的意大利 IVF 法，每位患者的 ICSI 取卵数量有限（1-3 个）。主要观察指标为受精、胚胎质量、着床和妊娠。
结果
本研究表明，注射结合透明质酸的精子（HA-ICSI）可显著改善胚胎质量和着床。
结论
如果更广泛的多中心随机研究将证实对 ICSI 结果的这些有益影响，那么 HA 可以被认为是 ICSI 前“生理”精子选择的常规选择。
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Fertil Steril. 2010 Feb;93(2):598-604. doi: 10.1016/j.fertnstert.2009.03.033. Epub 2009 Apr 25.
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