Reproductive Medicine Unit-GynePro Medical Centers, GynePro Medical, Via T. Cremona, 8-40137, Bologna, Italy.
J Assist Reprod Genet. 2010 Jan;27(1):13-6. doi: 10.1007/s10815-009-9380-0. Epub 2009 Dec 30.
Hyaluronic Acid (HA) has a role as "physiologic selector" for spermatozoa prior to intracytoplasmic sperm injection (ICSI). The objective of this study is to analyze the results achievable by the introduction of a routine HA-ICSI programme.
We retrospectively observed 293 couples treated with HA-ICSI versus 86 couples treated with conventional PVP-ICSI (historical control group). ICSI was performed on a limited number of oocytes per patient (1-3) according to Italian IVF law at the time of the study. Main outcome measures observed were: fertilization, embryo quality, implantation and pregnancy.
This study showed that Injection of HA-bound spermatozoa (HA-ICSI) significantly improves embryo quality and implantation.
If wider multi-center randomized studies will confirm these beneficial effects on ICSI outcome, HA could be considered as a routine choice for "physiologic" sperm selection prior to ICSI.
透明质酸(HA)在胞质内单精子注射(ICSI)之前作为精子的“生理选择器”发挥作用。本研究的目的是分析引入常规 HA-ICSI 方案可实现的结果。
我们回顾性观察了 293 对接受 HA-ICSI 治疗的夫妇与 86 对接受传统 PVP-ICSI(历史对照组)治疗的夫妇。根据当时的意大利 IVF 法,每位患者的 ICSI 取卵数量有限(1-3 个)。主要观察指标为受精、胚胎质量、着床和妊娠。
本研究表明,注射结合透明质酸的精子(HA-ICSI)可显著改善胚胎质量和着床。
如果更广泛的多中心随机研究将证实对 ICSI 结果的这些有益影响,那么 HA 可以被认为是 ICSI 前“生理”精子选择的常规选择。