Blázquez-Medela Ana M, López-Novoa José M, Martínez-Salgado Carlos
Unidad de Fisiopatología Renal y Cardiovascular, Instituto Reina Sofía de Investigación Nefrológica, Departamento de Fisiología y Farmacología, Universidad de Salamanca, 37007 Salamanca, Spain.
Curr Diabetes Rev. 2010 Mar;6(2):68-87. doi: 10.2174/157339910790909422.
In recent years, the amount of people suffering from diabetes has increased notably. This increase has led to an augmentation in secondary diseases; amongst them, diabetic nephropathy (DN) is one of the most relevant pathologies. DN provokes a decrease in glomerular filtration rate, which ends up in chronic renal failure. In the developed countries, DN is the first cause of chronic renal failure needing replacement therapy. Thus, this disease is responsible for a remarkable part of the public health costs in the Western countries. All of these facts have encouraged many scientists to perform their research on mechanism causing DN, improving our knowledge of its pathogenesis. In this review we summarize the most relevant facts on the physiopathology of DN.
近年来，患糖尿病的人数显著增加。这种增加导致了继发性疾病的增多；其中，糖尿病肾病（DN）是最相关的病理之一。DN会导致肾小球滤过率下降，最终导致慢性肾衰竭。在发达国家，DN是需要替代治疗的慢性肾衰竭的首要原因。因此，这种疾病在西方国家的公共卫生成本中占了相当大的一部分。所有这些事实促使许多科学家对DN的发病机制进行研究，增进了我们对其发病机理的了解。在这篇综述中，我们总结了DN生理病理学的最相关事实。
