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茵陈提取物可预防链脲佐菌素诱导的大鼠糖尿病肾病的发生。

Herba Artemisiae Capillaris Extract Prevents the Development of Streptozotocin-Induced Diabetic Nephropathy of Rat.

作者信息

Geng Jianan, Yu Xiaoyan, Liu Chunyu, Sun Chengbo, Guo Menghuan, Li Zhen, Jin Yingli, Zou Yinggang, Yu Jinghua

机构信息

Institute of Virology and AIDS, The First Hospital of Jilin University, Jilin University, Dongminzhu Street 519, Changchun 130000, China.

Department of Experimental Pharmacology and Toxicology, School of Pharmacy, Jilin University, Fujin Road 1266, Changchun 130021, China.

出版信息

Evid Based Complement Alternat Med. 2018 Feb 14;2018:5180165. doi: 10.1155/2018/5180165. eCollection 2018.

DOI:10.1155/2018/5180165
PMID:29636780
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5832121/
Abstract

Diabetic nephropathy (DN) is a major cause of end-stage renal disease throughout the world; until now there is no specific drug available. In this work, we use herba artemisiae capillaris extract (HACE) to alleviate renal fibrosis characterized by the excessive accumulation of extracellular matrix (ECM) in rats, aiming to investigate the protective effect of the HACE on DN. We found that the intragastric treatment of high-dose HACE could reverse the effect of streptozotocin not only to decrease the level of blood glucose and blood lipid in different degree but also further to improve renal functions. It is worth mentioning that the effect of HACE treatment was comparable to the positive drug benazepril. Moreover, we found that HACE treatment could on one hand inhibit oxidative stress in DN rats through regulating enzymatic activity for scavenging reactive oxygen species and on the other hand increase the ECM degradation through regulating the activity of metalloproteinase-2 (MMP-2) and the expression of tissue transglutaminase (tTG), which explained why HACE treatment inhibited ECM accumulation. On the basis of above experimental results, we conclude that HACE prevents DN development in a streptozotocin-induced DN rat model, and HACE is a promising candidate to cure DN in clinic.

摘要

糖尿病肾病（DN）是全球终末期肾病的主要病因；目前尚无特效药物。在本研究中，我们使用茵陈蒿提取物（HACE）减轻大鼠以细胞外基质（ECM）过度积聚为特征的肾纤维化，旨在研究HACE对DN的保护作用。我们发现，高剂量HACE灌胃治疗不仅能不同程度地逆转链脲佐菌素的作用，降低血糖和血脂水平，还能进一步改善肾功能。值得一提的是，HACE治疗的效果与阳性药物贝那普利相当。此外，我们发现HACE治疗一方面可通过调节清除活性氧的酶活性抑制DN大鼠的氧化应激，另一方面可通过调节金属蛋白酶-2（MMP-2）活性和组织转谷氨酰胺酶（tTG）表达增加ECM降解，这解释了HACE治疗抑制ECM积聚的原因。基于上述实验结果，我们得出结论，HACE可预防链脲佐菌素诱导的DN大鼠模型中DN的发展，HACE有望成为临床治疗DN的候选药物。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fc66/5832121/9e6b8a234ee0/ECAM2018-5180165.007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fc66/5832121/d4ebeb5daeee/ECAM2018-5180165.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fc66/5832121/a92eec91d182/ECAM2018-5180165.002.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fc66/5832121/e7d8e5a4a76d/ECAM2018-5180165.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fc66/5832121/f06386a57f34/ECAM2018-5180165.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fc66/5832121/e9e3ac740494/ECAM2018-5180165.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fc66/5832121/9e6b8a234ee0/ECAM2018-5180165.007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fc66/5832121/d4ebeb5daeee/ECAM2018-5180165.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fc66/5832121/a92eec91d182/ECAM2018-5180165.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fc66/5832121/c0caac8e5fec/ECAM2018-5180165.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fc66/5832121/e7d8e5a4a76d/ECAM2018-5180165.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fc66/5832121/f06386a57f34/ECAM2018-5180165.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fc66/5832121/e9e3ac740494/ECAM2018-5180165.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fc66/5832121/9e6b8a234ee0/ECAM2018-5180165.007.jpg

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