Millard F C, Nakielny R A, Makris M, Winfield D A
Department of Radiology, Royal Hallamshire Hospital, Sheffield, UK.
Br J Radiol. 1991 Feb;64(758):103-6. doi: 10.1259/0007-1285-64-758-103.
The objective of this study was to review and analyse the chest radiograph (CXR) appearances seen following high dose chemotherapy and autologous bone marrow transplantation (ABMT), and to identify any characteristic patterns. Thirty-one patients underwent ABMT between 1984 and 1989 for high grade lymphoma resistant to conventional chemotherapy. Their case notes and CXRs were reviewed in conjunction with the clinicians. In this small sample of patients, an acute interstitial pattern was seen with pulmonary oedema following bone marrow reinfusion in two cases of the 13 patients showing CXR changes (15%). Otherwise, the CXR changes following ABMT were not specific, although they did alert the clinician to the possibilities of recurrent lymphoma or opportunistic infection, enabling appropriate investigations and treatment to be instituted at an early stage. The complications and CXR changes did not differ greatly from those seen following allogeneic bone marrow transplantation.
本研究的目的是回顾和分析大剂量化疗及自体骨髓移植（ABMT）后胸部X线片（CXR）的表现，并确定是否存在任何特征性模式。1984年至1989年间，31例对传统化疗耐药的高级别淋巴瘤患者接受了ABMT。结合临床医生对他们的病历和胸部X线片进行了回顾。在这一小部分患者中，13例出现胸部X线片变化的患者中有2例（15%）在骨髓回输后出现急性间质模式并伴有肺水肿。否则，ABMT后的胸部X线片变化并无特异性，尽管这些变化确实提醒临床医生注意复发性淋巴瘤或机会性感染的可能性，从而能够在早期进行适当的检查和治疗。这些并发症和胸部X线片变化与异基因骨髓移植后的情况并无太大差异。
