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Regulation of HMG-CoA reductase, apoprotein-B and LDL receptor gene expression by the hypocholesterolemic drugs simvastatin and ciprofibrate in Hep G2, human and rat hepatocytes.降胆固醇药物辛伐他汀和环丙贝特对Hep G2细胞、人肝细胞及大鼠肝细胞中HMG - CoA还原酶、载脂蛋白B和低密度脂蛋白受体基因表达的调控
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The magnitude of decrease in hepatic very low density lipoprotein apolipoprotein B secretion is determined by the extent of 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibition in miniature pigs.小型猪肝脏极低密度脂蛋白载脂蛋白B分泌的降低幅度由3-羟基-3-甲基戊二酰辅酶A还原酶的抑制程度决定。
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本文引用的文献

1
Effect of apolipoprotein-B synthesis inhibition on liver triglyceride content in patients with familial hypercholesterolemia.载脂蛋白-B 合成抑制对家族性高胆固醇血症患者肝内甘油三酯含量的影响。
J Lipid Res. 2010 May;51(5):1057-62. doi: 10.1194/jlr.M002915. Epub 2009 Dec 14.
2
Liver histology in ICU patients dying from sepsis: a clinico-pathological study.死于脓毒症的重症监护病房患者的肝脏组织学:一项临床病理研究。
World J Gastroenterol. 2008 Mar 7;14(9):1389-93. doi: 10.3748/wjg.14.1389.
3
The broad spectrum of statin myopathy: from myalgia to rhabdomyolysis.他汀类药物所致肌病的广泛范围:从肌痛到横纹肌溶解。
Curr Opin Lipidol. 2007 Aug;18(4):401-8. doi: 10.1097/MOL.0b013e32825a6773.
4
Antisense apolipoprotein B therapy: where do we stand?反义载脂蛋白B疗法:我们目前的进展如何?
Curr Opin Lipidol. 2007 Aug;18(4):397-400. doi: 10.1097/MOL.0b013e328248b4ad.
5
Inhibition of microsomal triglyceride transfer protein in familial hypercholesterolemia.家族性高胆固醇血症中微粒体甘油三酯转运蛋白的抑制作用
N Engl J Med. 2007 Jan 11;356(2):148-56. doi: 10.1056/NEJMoa061189.
6
The safety and efficacy of achieving very low LDL-cholesterol concentrations with high dose statin therapy.高剂量他汀类药物治疗使低密度脂蛋白胆固醇浓度极低的安全性和有效性。
Curr Opin Lipidol. 2006 Dec;17(6):626-30. doi: 10.1097/MOL.0b013e328010872d.
7
Drug evaluation: ISIS-301012, an antisense oligonucleotide for the treatment of hypercholesterolemia.药物评价:ISIS - 301012,一种用于治疗高胆固醇血症的反义寡核苷酸。
Curr Opin Mol Ther. 2006 Oct;8(5):461-7.
8
Potent reduction of apolipoprotein B and low-density lipoprotein cholesterol by short-term administration of an antisense inhibitor of apolipoprotein B.通过短期给予载脂蛋白B反义抑制剂有效降低载脂蛋白B和低密度脂蛋白胆固醇
Circulation. 2006 Oct 17;114(16):1729-35. doi: 10.1161/CIRCULATIONAHA.105.606442. Epub 2006 Oct 9.
9
Hepatic and cardiovascular consequences of familial hypobetalipoproteinemia.家族性低β脂蛋白血症的肝脏和心血管后果。
Arterioscler Thromb Vasc Biol. 2005 Sep;25(9):1979-84. doi: 10.1161/01.ATV.0000176191.64314.07. Epub 2005 Jul 7.
10
Familial hypobetalipoproteinemia: genetics and metabolism.家族性低β脂蛋白血症:遗传学与代谢
Cell Mol Life Sci. 2005 Jun;62(12):1372-8. doi: 10.1007/s00018-005-4473-0.

Does inhibition of apolipoprotein B synthesis produce foie gras?

作者信息

Feingold Kenneth R

机构信息

Metabolism Section, Department of Veterans Affairs Medical Center, University of California San Francisco, San Francisco, CA 94121, USA.

出版信息

J Lipid Res. 2010 May;51(5):877-8. doi: 10.1194/jlr.E005140. Epub 2009 Dec 30.

DOI:10.1194/jlr.E005140
PMID:20042543
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2853454/
Abstract
摘要