Department of Ophthalmology, Glostrup Hospital, University of Copenhagen, Copenhagen, Denmark.
Invest Ophthalmol Vis Sci. 2010 May;51(5):2790-4. doi: 10.1167/iovs.09-4891. Epub 2009 Dec 30.
To examine dark-adapted retinal function in subjects with type 2 diabetes during transient hyperglycemia.
Twenty-four subjects with type 2 diabetes and minimal diabetic retinopathy were randomized to an oral glucose tolerance test (OGTT) or a fasting regimen. One study eye was kept in the dark-adapted state at all times. Full-field electroretinography (ffERG) and blood glucose measurements were performed at baseline and after 20, 80, 140, and 200 minutes.
Mean capillary glucose had increased 162% from the fasting baseline value when the concentration peaked in the OGTT group after 80 minutes (P < 0.0001). Concomitantly, rod b-wave amplitude had increased by 34% (P = 0.0007), whereas the a- and b-wave amplitudes of the standard combined rod-cone response had increased by 17% (P = 0.0013 and P = 0.0064). The dark-adapted 30-Hz flicker response was unaffected by hyperglycemia. The scotopic ffERG amplitudes rose and fell in phase with the glycemia. Implicit times did not change with the rise and fall in glycemia.
The change in scotopic signaling amplitude in the outer and middle layers of retina in subjects with diabetes was proportional to the change in capillary glucose. Cone amplitude was not influenced by hyperglycemia in this study.
研究 2 型糖尿病患者在短暂性高血糖期间暗适应视网膜功能。
24 例 2 型糖尿病伴轻度糖尿病视网膜病变患者随机分为口服葡萄糖耐量试验（OGTT）或禁食组。一只研究眼始终处于暗适应状态。在基线和 20、80、140 和 200 分钟时进行全视野视网膜电图（ffERG）和血糖测量。
OGTT 组 80 分钟时血糖浓度达到峰值，与空腹基线值相比，平均毛细血管血糖升高 162%（P<0.0001）。同时，棒状 b 波振幅增加了 34%（P=0.0007），而标准的棒状-锥状联合反应的 a 波和 b 波振幅分别增加了 17%（P=0.0013 和 P=0.0064）。高血糖对暗适应 30-Hz 闪烁反应没有影响。暗适应 ffERG 振幅与血糖同步上升和下降。潜伏期随血糖的上升和下降而变化。
糖尿病患者视网膜外、中层暗适应信号振幅的变化与毛细血管血糖的变化成正比。在这项研究中，高血糖对锥体细胞振幅没有影响。
Zotero 插件