MRC Unit for Lifelong Health and Aging, Department of Epidemiology and Public Health, University College London, London, UK.
J Hypertens. 2010 Apr;28(4):679-86. doi: 10.1097/HJH.0b013e328335de7b.
To assess the relationship between patterns of overweight during adulthood and systolic (SBP) and diastolic (DBP) blood pressure (BP) at age 53.
Data are from 3035 male and female participants of the 1946 British birth cohort study. Body mass index (BMI) was obtained at ages 20, 26, 36, 43 and 53 years. Censored regression models accounting for medication were used to investigate associations of BP at 53 years with overweight (BMI > 25 kg/m) at each age, age at first overweight and conditional weight gain. Sex interactions were also examined.
Overweight at all ages except for 20 years in men was positively associated with BP at 53 years. After adjusting for current BMI, only overweight at age 43 contained additional information on BP in men. Men who were overweight at age 26 had a SBP 8.7 mmHg higher [95% confidence interval (CI) 4.4-13.0] than those first overweight at 53 years. Similar patterns but smaller associations were seen in women [P(interaction) < 0.001). All periods of adult weight gain (26-36, 36-43, 43-53 years) were associated with a higher BP. BMI tracked strongly through adulthood, the BMI at 53 years in men first overweight at 26 was 30.9 kg/m (95% CI 30.5-31.4) compared to 26.4 (95% CI 26.3-26.6) in those first overweight at age 53.
Early adult overweight and all periods of adult weight gain irrespective of earlier BMI were associated with higher BPs. This highlights the importance for later health of preventing overweight in early adulthood.
评估成年期超重模式与 53 岁时收缩压（SBP）和舒张压（DBP）血压之间的关系。
数据来自 1946 年英国出生队列研究的 3035 名男性和女性参与者。在 20、26、36、43 和 53 岁时获得体重指数（BMI）。使用考虑药物的删截回归模型，调查 53 岁时的 BP 与每个年龄、首次超重年龄和条件体重增加时超重（BMI > 25 kg/m）的关联。还检查了性别交互作用。
除男性 20 岁外，所有年龄的超重均与 53 岁时的 BP 呈正相关。在校正当前 BMI 后，只有 43 岁时的超重包含了男性 BP 的附加信息。26 岁时超重的男性收缩压比 53 岁时首次超重的男性高 8.7 mmHg[95%置信区间（CI）为 4.4-13.0]。女性中观察到类似的模式但关联较小[P（交互）<0.001）。所有成人增重期（26-36、36-43、43-53 岁）与更高的 BP 相关。BMI 在成年期内跟踪性很强，26 岁时首次超重的男性在 53 岁时的 BMI 为 30.9 kg/m（95% CI 30.5-31.4），而首次超重时的 BMI 为 26.4 kg/m（95% CI 26.3-26.6）在 53 岁。
成年早期超重和所有成人增重期，无论早期 BMI 如何，都与更高的 BPs 相关。这突出表明，预防成年早期超重对以后的健康非常重要。
