Shantou University Medical College, Shantou, China.
Department of Cardiology, Second Affiliated Hospital of Shantou University Medical College, Shantou, China.
Heart. 2022 May;108(9):683-688. doi: 10.1136/heartjnl-2021-320278. Epub 2022 Feb 21.
The aim of this study was to examine the association between age at onset of overweight and incident hypertension.
We analysed 4742 participants with new-onset overweight from the Kailuan study between 2006 and 2015 and and 4742 age-matched and sex-matched controls selected randomly from the same cohort but with normal weight. Participants were compared with respect to subsequent risk of hypertension, with sub-HR calculated with the Fine and Gray model, according to age of onset of overweight.
Over a mean follow-up period of 5.17 years, 1642 overweight participants (34.6%) and 1293 normal-weight controls (27.3%) were subsequently diagnosed with hypertension. The median age at onset of overweight was 49.1 years. Compared with normal-weight controls, the multivariable-adjusted sub-HR for hypertension among participants with onset of overweight at 18-39 years of age, 40-49 years of age, 50-59 years of age and ≥60 years of age was 1.38 (95% CI 1.11 to 1.72), 1.27 (95% CI 1.09 to 1.49), 1.23 (95% CI 1.09 to 1.38) and 1.14 (95% CI 0.99 to 1.32), respectively. Onset of overweight in each age range was significantly associated with increased risk of hypertension, except for the group with onset at ≥60 years of age. The risk increased with each decade of attenuation of age at onset, peaking at 18-39 years of age.
Younger age at onset of overweight across adulthood was associated with significantly increased risk of hypertension, with the highest relative risk among participants with onset of overweight at 18-39 years of age.
本研究旨在探讨超重发病年龄与高血压发病的关系。
我们分析了 2006 年至 2015 年期间开滦研究中出现新超重的 4742 名参与者，以及从同一队列中随机选择的 4742 名年龄和性别匹配的正常体重对照者。根据超重发病年龄，使用 Fine 和 Gray 模型计算亚危险比，比较参与者随后发生高血压的风险。
在平均 5.17 年的随访期间，1642 名超重参与者（34.6%）和 1293 名正常体重对照者（27.3%）随后被诊断为高血压。超重发病的中位年龄为 49.1 岁。与正常体重对照组相比，18-39 岁、40-49 岁、50-59 岁和≥60 岁发病的超重参与者中，高血压的多变量调整亚危险比为 1.38（95%可信区间 1.11 至 1.72）、1.27（95%可信区间 1.09 至 1.49）、1.23（95%可信区间 1.09 至 1.38）和 1.14（95%可信区间 0.99 至 1.32）。每个年龄范围的超重发病均与高血压发病风险增加显著相关，≥60 岁发病组除外。发病年龄每推迟 10 年，风险增加，在 18-39 岁时达到峰值。
成年期超重发病年龄越小，高血压发病风险显著增加，18-39 岁发病的参与者风险最高。
