Department of Orthopaedics, NYU Hospital for Joint Diseases, New York, NY 10010, USA.
Spine (Phila Pa 1976). 2010 Jan 1;35(1):18-25. doi: 10.1097/BRS.0b013e3181b79169.
Computed Tomographic Analysis of the Porcine Scoliosis Model.
To describe the spinal and rib cage modifications using computed tomography (CT).
Optimal development of nonfusion techniques for treatment of adolescent idiopathic scoliosis (AIS) requires a reliable large animal model that achieves spinal and rib cage modifications similar to AIS. Previous work has described the global 3-dimensional nature of the progressive deformity.
This IACUC-approved study includes 11 extracted scoliotic spines from a previous investigation. Scoliosis was induced through unilateral posterior ligament tethering of the spine via pedicle screw fixation, and ipsilateral rib cage tethering. CT analysis was used to quantify rib cage asymmetry, axial rotation, and wedging of the apical functional unit (2 vertebrae and intervening disc) for each specimen.
The mean coronal Cobb angle was 55.7 degrees (n = 11). Vertebral and intervertebral heights of the apical functional unit demonstrated convex heights (untethered) were always larger than concave (tethered) heights (P < 0.05). Axial rotation was maximal (mean, 20 degrees ) at 1 to 2 levels distal to the coronal apex. Maximal rib cage asymmetry was demonstrated at the transverse apex with significant coupling of the rotational and rib cage modifications (r = 0.82). A large initial Cobb index (tether tension) was significantly correlated with vertebral and intervertebral wedging and coronal curve progression.
The present study has used CT analysis to analyze spinal and rib cage modifications in the Porcine Scoliosis Model. Placement of a unilateral ligamentous spinal tether combined with concave rib cage ligament tethering during the rapid growth stage of the Yorkshire pig results in significant apical vertebral and intervertebral wedging and rotational and rib cage modifications. The porcine model is a reliable and duplicable model for scoliosis, which bears significant similarities to AIS.
猪脊柱侧凸模型的计算机断层扫描分析。
用计算机断层扫描（CT）描述脊柱和胸廓的改变。
为了开发用于治疗青少年特发性脊柱侧凸（AIS）的非融合技术，需要一种可靠的大动物模型，这种模型能够实现类似于 AIS 的脊柱和胸廓改变。之前的研究已经描述了渐进性畸形的整体三维性质。
这项经过 IACUC 批准的研究包括来自之前一项研究的 11 个提取的脊柱侧凸脊柱。通过椎弓根螺钉固定进行单侧后路韧带结扎和同侧胸廓韧带结扎来诱导脊柱侧凸。使用 CT 分析来量化每个标本的胸廓不对称、轴向旋转和顶椎功能单元（2 个椎体和相邻椎间盘）的楔形。
平均冠状 Cobb 角为 55.7 度（n = 11）。顶椎功能单元的椎体和椎间高度显示凸侧（未结扎）的高度总是大于凹侧（结扎）的高度（P < 0.05）。轴向旋转在距冠状顶点 1 到 2 个节段处最大（平均 20 度）。最大的胸廓不对称发生在横突顶点，并且旋转和胸廓改变之间存在显著的耦合（r = 0.82）。较大的初始 Cobb 指数（结扎张力）与椎体和椎间楔形及冠状曲线进展显著相关。
本研究使用 CT 分析分析了猪脊柱侧凸模型中的脊柱和胸廓改变。在约克夏猪生长快速阶段，单侧韧带性脊柱固定联合凹侧胸廓韧带固定可导致明显的顶椎椎体和椎间楔形及旋转和胸廓改变。猪模型是脊柱侧凸的一种可靠且可复制的模型，与 AIS 有很大的相似性。
