VA VISN 19 Mental Illness Research Education and Clinical Center, Denver, Colorado, USA.
J Head Trauma Rehabil. 2010 Sep-Oct;25(5):307-12. doi: 10.1097/HTR.0b013e3181cada03.
Analyze the contribution of mild traumatic brain injury (mTBI) and/or posttraumatic stress disorder (PTSD) to the endorsement of postconcussive (PC) symptoms during Post Deployment Health Assessment. Determine whether a combination of mTBI and PTSD was more strongly associated with symptoms than either condition alone.
Cross-sectional study design where both the exposure, mTBI and/or PTSD, and the outcomes of interest, PC symptoms, were ascertained after return from deployment. Subjects were injured soldiers (n = 1247) from one Fort Carson Brigade Combat Team (n = 3973).
Positive history of PC symptoms.
PTSD and mTBI together were more strongly associated with having PC symptoms (adjusted prevalence ratio 6.27; 95% CI: 4.13-9.43) than either mTBI alone (adjusted prevalence ratio = 4.03; 95% CI: 2.67-6.07) or PTSD alone (adjusted prevalence ratio = 2.74; 95% CI: 1.58-4.74) after adjusting for age, gender, education, rank, and Military Occupational Specialty.
In soldiers with histories of physical injury, mTBI and PTSD were independently associated with PC symptom reporting. Those with both conditions were at greater risk for PC symptoms than those with either PTSD, mTBI, or neither. Findings support the importance of continued screening for both conditions with the aim of early identification and intervention.
分析轻度创伤性脑损伤(mTBI)和/或创伤后应激障碍(PTSD)对部署后健康评估中出现的脑震荡后(PC)症状的影响。确定 mTBI 和 PTSD 的组合与症状的相关性是否强于任何一种单独的疾病。
采用横断面研究设计,在从部署中返回后确定暴露因素(mTBI 和/或 PTSD)和感兴趣的结局(PC 症状)。研究对象为来自卡森堡的一个旅战斗队的受伤士兵(n = 1247)(n = 3973)。
有 PC 症状的病史。
与 mTBI 单独(调整后的患病率比 = 4.03;95%CI:2.67-6.07)或 PTSD 单独(调整后的患病率比 = 2.74;95%CI:1.58-4.74)相比,mTBI 和 PTSD 同时存在与出现 PC 症状的相关性更强(调整后的患病率比 6.27;95%CI:4.13-9.43),调整后的因素包括年龄、性别、教育程度、军衔和军事职业专业。
在有身体损伤史的士兵中,mTBI 和 PTSD 与 PC 症状的报告独立相关。与 PTSD、mTBI 或两者都没有的患者相比,同时存在这两种情况的患者发生 PC 症状的风险更高。这些发现支持了继续对这两种情况进行筛查的重要性,目的是早期发现和干预。