Department of Surgery, the Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310009, China.
J Zhejiang Univ Sci B. 2010 Jan;11(1):22-6. doi: 10.1631/jzus.B0900166.
Somatostatinoma is a very rare neuroendocrine tumor that originates from D cells and accounts for less than 1% of all gastrointestinal endocrine tumors. The duodenum is the most frequent site for this tumor, followed by the pancreas. We here describe a 46-year-old Chinese woman who developed pancreatic somatostatinoma presenting with the characteristic "inhibitory" syndrome, but the symptoms were obscure and seemingly uncorrelated. This case is also unique for its large tumor size and mixed pathological pattern. Distal pancreatectomy was performed, and the patient has remained well since operation. As the syndromes of somatostatinoma may be obscure and atypical, clinicians should review all clinical findings to obtain an accurate diagnosis. Aggressive surgery is preferred to improve the survival.
生长抑素瘤是一种非常罕见的神经内分泌肿瘤，起源于 D 细胞，占所有胃肠道内分泌肿瘤的不到 1%。十二指肠是这种肿瘤最常见的部位，其次是胰腺。我们在此描述了一位 46 岁的中国女性，她患有胰腺生长抑素瘤，表现出典型的“抑制”综合征，但症状模糊且似乎没有关联。这种情况也因其肿瘤体积大且病理模式混合而独特。进行了远端胰腺切除术，患者自手术后一直恢复良好。由于生长抑素瘤的综合征可能不明显且不典型，临床医生应综合所有临床发现以获得准确的诊断。积极的手术是首选，以提高生存率。
