Stelow Edward B, Woon Carolyn, Pambuccian Stefan E, Thrall Michael, Stanley Michael W, Lai Rebecca, Mallery Shawn, Gulbahce H Evin
Department of Pathology, University of Virginia, Charlottesville, 22908, USA.
Diagn Cytopathol. 2005 Aug;33(2):100-5. doi: 10.1002/dc.20305.
Pancreatic somatostatinoma is a rare pancreatic endocrine neoplasm representing as little as 1% of pancreatic endocrine neoplasms (PENs). The histologic features of this tumor are like those of other PENs, except that it commonly forms acinar structures and often has cells with abundant, granular cytoplasm. We have recently encountered two of these neoplasms sampled by endoscopic ultrasound (EUS)-guided fine-needle aspiration (FNA). We discuss the cytologic and immunohistochemical findings of these two cases and the cytologic similarities these neoplasms share with pancreatic acinar-cell carcinoma (PACC). We review the cytologic features of PEN and PACC and discuss the importance of cell block immunohistochemistry in the diagnosis of pancreatic neoplasia sampled by EUS-guided FNA.
胰腺生长抑素瘤是一种罕见的胰腺内分泌肿瘤，仅占胰腺内分泌肿瘤（PENs）的1%。该肿瘤的组织学特征与其他PENs相似，不同之处在于它通常形成腺泡结构，且细胞常含有丰富的颗粒状细胞质。我们最近遇到了两例通过内镜超声（EUS）引导下细针穿刺抽吸（FNA）取样的此类肿瘤。我们讨论了这两例病例的细胞学和免疫组化结果，以及这些肿瘤与胰腺腺泡细胞癌（PACC）共有的细胞学相似性。我们回顾了PEN和PACC的细胞学特征，并讨论了细胞块免疫组化在EUS引导下FNA取样的胰腺肿瘤诊断中的重要性。
