Crane M M, Keating M J
University of Texas Health Science Center, School of Public Health, Houston 77030.
Cancer. 1991 Apr 15;67(8):2211-4. doi: 10.1002/1097-0142(19910415)67:8<2211::aid-cncr2820670835>3.0.co;2-4.
A subset of patients with acute nonlymphocytic leukemia (ANLL) have evidence of a myelodysplastic syndrome (MDS), low infiltrate leukemia, or other preleukemic condition that may be present for several months before onset of disease. The hypothesis that these conditions act as markers for environmentally induced cancer was examined in 270 ANLL patients, 46 with a preleukemic phase and 224 with an acute onset. Although the effects of previously identified risk factors (male sex, age older than 50 years, prior cytotoxic therapy) were demonstrated, no associations with common environmental conditions (cigarette smoking, alcohol use, occupations with exposure to chemicals or radiation) were present with the exception of hobbies involving potential chemical exposure, odds ratio (OR) and 95% confidence intervals = 4.2 (1.4 to 12.3) and self-reported exposure to pesticides, OR = 10.2 (1.8 to 63.1). These may be chance associations although a previous case-control study of MDS reported similar findings.
一部分急性非淋巴细胞白血病（ANLL）患者有骨髓增生异常综合征（MDS）、低浸润性白血病或其他白血病前期病症的证据，这些病症可能在疾病发作前数月就已存在。在270例ANLL患者中检验了这些病症作为环境诱导癌症标志物的假说，其中46例有白血病前期阶段，224例急性起病。尽管已证实了先前确定的危险因素（男性、年龄大于50岁、先前的细胞毒性治疗）的影响，但除了涉及潜在化学物暴露的爱好（优势比[OR]和95%置信区间=4.2[1.4至12.3]）以及自我报告的农药暴露（OR=10.2[1.8至63.1]）外，未发现与常见环境状况（吸烟、饮酒、接触化学物或辐射的职业）有关联。尽管先前一项关于MDS的病例对照研究报告了类似结果，但这些可能是偶然关联。
