通过串联的氧迈克尔加成-维蒂希烯烃化反应途径合成高度官能化的 C-糖苷。
Synthesis of densely functionalised C-glycosides by a tandem oxy Michael addition-Wittig olefination pathway.
机构信息
Organic Chemistry Division, Central Leather Research Institute, Chennai, India.
出版信息
Carbohydr Res. 2010 Feb 26;345(4):457-61. doi: 10.1016/j.carres.2009.12.014. Epub 2009 Dec 16.
PMID:20044078
Abstract
Wittig olefination of 5,6-dideoxy-5,6-anhydro-6-nitro-D-glucofuranose (5) triggered a concomitant cyclisation via oxy Michael addition of the C2-hydroxyl group resulting in the formation of C-vinyl glycosides with Z-olefinic geometry.
摘要
5,6-二脱氧-5,6-脱水-6-硝基-D-葡萄糖呋喃糖（5）的Wittig 烯烃化反应引发了通过 C2-羟基的氧迈克尔加成的伴随环化，导致形成具有 Z-烯烃几何形状的 C-乙烯基糖苷。
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