William S. Middleton Memorial Veterans Hospital, Geriatric Research Educational and Clinical Center, Madison, WI, USA.
Maturitas. 2010 Feb;65(2):131-7. doi: 10.1016/j.maturitas.2009.12.014. Epub 2009 Dec 30.
Factors contributing to increased risk for Alzheimer's disease (AD) include age, sex, genes, and family history of AD. Several risk factors for AD are endogenous; however, accumulating evidence implicates modifiable risk factors in the pathogenesis of AD. Although the continued task of identifying new genes will be critical to learning more about the disease, several research findings suggest that potentially alterable environmental factors influence genetic contributions, providing targets for disease prevention and treatment. Here, we review midlife risk factors for AD, and address the potential for therapeutic intervention in midlife.
导致阿尔茨海默病（AD）风险增加的因素包括年龄、性别、基因和 AD 的家族史。AD 的几个风险因素是内源性的；然而，越来越多的证据表明，可改变的风险因素在 AD 的发病机制中起作用。虽然确定新基因的持续任务对于了解该疾病至关重要，但一些研究结果表明，潜在可改变的环境因素会影响遗传贡献，为疾病的预防和治疗提供了靶点。在这里，我们回顾了 AD 的中年风险因素，并探讨了中年进行治疗干预的可能性。
