Marathe G K, Krishnakantha T P, D'Souza C J
Department of Studies in Biochemistry, University of Mysore, India.
Cell Biol Int Rep. 1991 Jan;15(1):85-90. doi: 10.1016/0309-1651(91)90085-w.
PAF-Acether fraction derived from stimulated AK-5 tumour cells, aggregated human platelets. The platelet aggregating ability increased linearly with increasing concentration of the stimulant, calcium ionophore A23187, and reached a maximum at 6 microM in 25 minutes. This factor had biological and chemical properties identical to authentic PAF-acether. Our results demonstrate that, although PAF-acether is produced mainly from pro-inflammatory cells, it appears to be produced even in tumour cells.
源自受刺激的AK-5肿瘤细胞的血小板活化因子（PAF）组分可使人类血小板聚集。血小板聚集能力随刺激剂钙离子载体A23187浓度的增加呈线性增加，并在25分钟内于6微摩尔时达到最大值。该因子具有与正宗血小板活化因子相同的生物学和化学特性。我们的结果表明，尽管血小板活化因子主要由促炎细胞产生，但它似乎也能在肿瘤细胞中产生。
