CDX2 在皮肤转移性癌和乳腺外派杰病中的表达。
CDX2 expression in cutaneous metastatic carcinomas and extramammary Paget's Disease.
机构信息
Laboratory of Dermatopathology, Ed. Herriot Hospital Group, 69437 Lyon cedex 03, France.
出版信息
Anticancer Res. 2009 Dec;29(12):5033-7.
BACKGROUND
CDX2 is a gene involved in the regulation of intestinal cell proliferation/differentiation. It is considered specific for enterocytes and has been used for the diagnosis of primary and metastatic colon adenocarcinoma. The aim of this study was to assess the usefulness of CDX2 in the diagnosis of cutaneous metastatic tumors and extramammary Paget's disease.
MATERIALS AND METHODS
The immunohistochemical expression of CDX2 was studied in 68 cutaneous metastatic tumors of various origins and 14 specimens of extramammary Paget's disease.
RESULTS
CDX2 expression was found in 3/6 metastases of colon adenocarcinoma, 1/1 metastasis of urothelial carcinoma and 1/2 extramammary Paget's disease.
CONCLUSION
CDX2 appears to be specific for cutaneous metastases from intestinal and urothelial carcinomas and is a useful diagnostic marker of these tumors. However, its sensitivity is modest, and we advocate its use in conjunction with additional immunohistochemical markers. CDX2 seems useful for the diagnosis of extramammary Paget's disease associated with an underlying colorectal tumor.
背景
CDX2 是一种参与调节肠道细胞增殖/分化的基因。它被认为是肠细胞特异性的，已被用于诊断原发性和转移性结肠腺癌。本研究旨在评估 CDX2 在诊断皮肤转移性肿瘤和乳房外Pagets 病中的作用。
材料和方法
研究了 68 例来自不同部位的皮肤转移性肿瘤和 14 例乳房外 Pagets 病标本中 CDX2 的免疫组织化学表达。
结果
CDX2 在 3/6 例结肠腺癌转移、1/1 例尿路上皮癌转移和 1/2 例乳房外 Pagets 病中表达。
结论
CDX2 似乎是肠道和尿路上皮癌皮肤转移的特异性标志物，是这些肿瘤的有用诊断标志物。然而，其敏感性适中，我们主张将其与其他免疫组织化学标志物联合使用。CDX2 似乎对伴有结直肠肿瘤的乳房外 Pagets 病的诊断有用。
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