Tanabe H, Kishigawa T, Sayama S, Tanaka T
Department of Dermatology, Tenri Hospital, Tenri City, Japan.
Dermatology. 2001;202(3):249-51. doi: 10.1159/000051646.
Extramammary Paget's disease is a primary carcinoma with apocrine differentiation that begins within the epidermis. Extramammary Paget's disease and squamous-cell carcinoma (SCC) have different neoplastic origins and are different both clinically and histologically. Until now the concurrence of extramammary Paget's disease and SCC in the same area has not been reported to our knowledge. We report on a 76-year-old man with extramammary Paget's disease affecting a large region of the genital area with SCC within the same area. A skin biopsy specimen showed the coexistence of typical Paget's disease and highly differentiated SCC invading the dermis. Immunohistochemical staining of both cell types was completely different.
乳腺外佩吉特病是一种起源于表皮的具有大汗腺分化的原发性癌。乳腺外佩吉特病与鳞状细胞癌（SCC）具有不同的肿瘤起源，在临床和组织学上均不相同。据我们所知，此前尚未有在同一区域同时出现乳腺外佩吉特病和SCC的报道。我们报告了一名76岁男性，其生殖器区域的大片区域患有乳腺外佩吉特病，且同一区域存在SCC。皮肤活检标本显示典型的佩吉特病与侵袭真皮的高分化SCC并存。两种细胞类型的免疫组织化学染色完全不同。
