糖尿病合并轻度认知障碍患者发生痴呆的风险。
Risk of developing dementia in people with diabetes and mild cognitive impairment.
机构信息
National Institute for Health Research (NIHR) Biomedical Research Centre for Mental Health, Section of Old Age Psychiatry, Institute of Psychiatry, London, UK.
出版信息
Br J Psychiatry. 2010 Jan;196(1):36-40. doi: 10.1192/bjp.bp.109.067942.
BACKGROUND
Diabetes mellitus is associated with cognitive dysfunction, but it is not clear whether the disorder increases the risk of conversion from mild cognitive impairment to dementia.
AIMS
To determine the association between diabetes mellitus and dementia conversion in people with mild cognitive impairment (Peterson's criteria) in a prospective community-based study.
METHOD
People over 65 years old were approached through primary care practices in south London, UK, and those with mild cognitive impairment (n = 103) were followed up for 4 years. Presence of diabetes was established from self-report and information from general practitioners.
RESULTS
Nineteen participants progressed to dementia, with the predominant diagnosis being probable or possible Alzheimer's disease (in 84%). Only diabetes mellitus was associated with progression to dementia (hazard ratio 2.9, 95% CI 1.1-7.3) after adjustment for sociodemographic factors, APOE4, premorbid IQ and other health conditions.
CONCLUSIONS
Diabetes mellitus increases not only the risks of dementia and mild cognitive impairment but also the risk of progression from such impairment to dementia.
背景
糖尿病与认知功能障碍有关，但尚不清楚该疾病是否会增加轻度认知障碍向痴呆转化的风险。
目的
在一项前瞻性社区研究中，确定糖尿病与轻度认知障碍（Peterson 标准）患者痴呆转化之间的关系。
方法
通过英国伦敦南部的初级保健机构接触 65 岁以上的人群，并对 103 名轻度认知障碍患者进行了 4 年的随访。通过自我报告和全科医生的信息确定是否存在糖尿病。
结果
19 名参与者进展为痴呆，主要诊断为可能或很可能的阿尔茨海默病（84%）。仅糖尿病与痴呆进展相关（风险比 2.9，95%CI 1.1-7.3），校正社会人口因素、APOE4、发病前智商和其他健康状况后。
结论
糖尿病不仅增加了痴呆和轻度认知障碍的风险，而且增加了从这种损害发展为痴呆的风险。
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