Ong A C, Eisen V, Rennie D P, Homburg R, Lachelin G C, Jacobs H S, Slater J D
Cobbold Laboratories, Middlesex Hospital, London, UK.
Clin Endocrinol (Oxf). 1991 Jan;34(1):43-9. doi: 10.1111/j.1365-2265.1991.tb01734.x.
Two patients with severe ovarian hyperstimulation syndrome are described. Increased plasma concentrations of immunoradiometrically determined total renin are shown, together with greatly increased plasma levels of active renin and aldosterone. These very high values for total renin, renin activity and aldosterone were not suppressed when extracellular compartments were greatly expanded; the values subsequently declined to normal levels, despite the use of diuretics. This suggested that the renin was of non-renal origin since its production was apparently unaffected by influences which control juxtaglomerular secretion. The high concentrations of the renin-angiotensin-aldosterone system suggest that it contributes to the genesis of the ovarian hyperstimulation syndrome.
本文描述了两名患有严重卵巢过度刺激综合征的患者。研究显示，通过免疫放射测定法测得的血浆总肾素浓度升高，同时活性肾素和醛固酮的血浆水平也大幅升高。当细胞外液显著增加时，这些总肾素、肾素活性和醛固酮的极高值并未受到抑制；尽管使用了利尿剂，这些值随后仍降至正常水平。这表明肾素并非来源于肾脏，因为其产生显然不受控制肾小球旁器分泌的因素影响。肾素 - 血管紧张素 - 醛固酮系统的高浓度表明，它在卵巢过度刺激综合征的发生过程中起作用。
