A storage protein-like Trypsin inhibitor from the Moth Bean (Phaseolus acutifolius) with antiproliferative activity toward lymphoma cells.

作者信息

Ma D Z, Sun J, Zhang G Q, Wang H X, Ng T B

机构信息

State Key Laboratory for Agrobiotechnology and Department of Microbiology, China Agricultural University, Beijing 100193, China.

出版信息

Protein Pept Lett. 2010 Jun;17(6):782-8. doi: 10.2174/092986610791190408.

DOI:10.2174/092986610791190408

PMID:20044920

Abstract

A 26-kDa trypsin inhibitor with an N-terminal sequence resembling storage proteins was purified from moth beans (Phaseolus acutifolius). It dose-dependently inhibited trypsin with an IC(50) value of about 0.38 microM. It inhibited [methyl-(3)H] thymidine incorporation by lymphoma MBL2 cells with an IC(50) value of 20 microM.

摘要