University of Amsterdam, Cognitive and Systems Neuroscience, Center for Neuroscience, Swammerdam Institute for Life Sciences, Faculty of Science, The Netherlands.
Neurobiol Learn Mem. 2010 Mar;93(3):422-7. doi: 10.1016/j.nlm.2009.12.009. Epub 2010 Jan 4.
In monkeys and rats, neural activity patterns during learning are reactivated during subsequent periods of rest or sleep. According to the reactivation-consolidation account, this process underlies the consolidation of memories. Brain imaging studies have extended these findings to humans during sleep, but not yet, during rest. Here, we show that learning-related reactivation also occurs in humans during rest. During functional MRI-scanning, participants trained on a perceptuomotor task flanked by rest periods. During training, we found robust activity in the superior parietal cortex. During post-training rest, this same area reactivated. We also found a link between parietal reactivation and learning. Activity in superior parietal cortex was associated with learning during training, and a control group that did not train on the perceptuomotor task did not show any difference between the pre- and post-training rest blocks in this region. These findings indicate that, during rest, reactivation also occurs in humans. This process may contribute to consolidation of perceptuomotor memories.
在猴子和老鼠中，学习过程中的神经活动模式在随后的休息或睡眠期间会被重新激活。根据再激活-巩固假说，这个过程是记忆巩固的基础。脑成像研究已经将这些发现扩展到了人类在睡眠期间，但还没有扩展到休息期间。在这里，我们表明在人类休息期间也会发生与学习相关的再激活。在功能磁共振成像扫描期间，参与者在感知运动任务之间进行休息。在训练过程中，我们发现顶叶上皮质有强烈的活动。在训练后的休息期间，同一区域会重新激活。我们还发现顶叶重新激活与学习之间存在联系。顶叶上皮质的活动与训练期间的学习有关，而一个没有在感知运动任务上进行训练的对照组在该区域的训练前和训练后休息期间没有显示出任何差异。这些发现表明，在休息期间，人类也会发生再激活。这个过程可能有助于感知运动记忆的巩固。
