Department of Medicine, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, Canada.
Int J Infect Dis. 2010 Sep;14 Suppl 3:e239-41. doi: 10.1016/j.ijid.2009.08.021. Epub 2009 Dec 31.
We describe the first reported case of gonococcal septic shock with associated acute respiratory distress syndrome and multisystem organ failure, in which the patient made a full recovery, and add to the paucity of descriptive literature on gonococcal sepsis. The case was a 36-year-old previously healthy Aboriginal female from northern Canada. Treatment included fluid resuscitation, vasoactive drugs, mechanical ventilation, antimicrobial therapy, corticosteroid replacement, activated protein C, and general supportive care. In addition to being the first reported case of gonococcal septic shock with associated acute respiratory distress syndrome and multisystem organ failure in which the patient made a full clinical recovery this is also the first case of gonococcal septic shock treated with activated protein C; an association between its use and the favorable outcome is postulated, but cannot be confirmed.
我们描述了首例报告的淋球菌性败血症性休克伴急性呼吸窘迫综合征和多器官功能衰竭的病例，该患者完全康复，并补充了关于淋球菌败血症的描述性文献的不足。该病例为来自加拿大北部的一名 36 岁的既往健康的土著女性。治疗包括液体复苏、血管活性药物、机械通气、抗菌治疗、皮质类固醇替代、活化蛋白 C 和一般支持性护理。这不仅是首例报告的淋球菌性败血症性休克伴急性呼吸窘迫综合征和多器官功能衰竭的病例，而且也是首例用活化蛋白 C 治疗的淋球菌性败血症性休克病例；推测其使用与有利的结果之间存在关联，但无法得到证实。
