Department of Tumor Markers, The Maria Sklodowska-Curie Memorial Institute and Oncology Centre ul. W.K. Roentgena 5, 02-781 Warszawa, Poland.
Clin Biochem. 2010 Apr;43(6):604-8. doi: 10.1016/j.clinbiochem.2009.12.018. Epub 2010 Jan 4.
Investigating relationship between bone markers, cytokines and conventional prognostic parameters in patients with multiple myeloma (MM) and to assess the clinical application of bone turnover markers.
Sixty-four patients with MM were examined before treatment and followed for survival for over 7 years. Serum concentrations of bone markers and cytokines were determined by the Roche and R&D kits, respectively. Standard deviation scores (SDS) were employed to normalize values.
Collagen fragments (beta-CTX) were elevated in 47%, procollagen I amino-terminal propeptide (PINP)-in 28%, and osteocalcin (OC) in 11% of patients. The values of the SDS of PINP and OC, but not beta-CTX significantly decreased with MM stage. beta-CTX inversely correlated with vascular endothelial growth factor (VEGF) and albumin, and directly correlated with serum macrophage colony-stimulating factor (M-CSF). OC values correlated with albumin and beta2-microglobulin. PINP inversely correlated with LDH. The SDS values of PINP were significantly lower in MM patients with advanced bone disease.
Circulating PINP concentration may be a useful marker for monitoring of treatment of multiple myeloma patients with bone lytic lesions, in particular, of patients treated with preoteasome inhibitors.
研究多发性骨髓瘤（MM）患者骨标志物、细胞因子与常规预后参数之间的关系，并评估骨转换标志物的临床应用。
对 64 例 MM 患者进行治疗前检查，并进行了超过 7 年的生存随访。采用罗氏和 R&D 试剂盒分别检测血清骨标志物和细胞因子浓度。采用标准偏差评分（SDS）对数值进行归一化。
47%的患者胶原片段（β-CTX）升高，28%的患者前胶原 I 氨基端前肽（PINP）升高，11%的患者骨钙素（OC）升高。PINP 和 OC 的 SDS 值随着 MM 分期的增加而显著降低，但β-CTX 则相反。β-CTX 与血管内皮生长因子（VEGF）和白蛋白呈负相关，与血清巨噬细胞集落刺激因子（M-CSF）呈正相关。OC 值与白蛋白和β2-微球蛋白相关。PINP 的 SDS 值在有进展性骨病的 MM 患者中显著降低。
循环 PINP 浓度可能是监测多发性骨髓瘤患者溶骨性病变治疗的有用标志物，特别是接受蛋白酶体抑制剂治疗的患者。
