Oncology Therapy Area, AstraZeneca, Alderley Park, Macclesfield, Cheshire SK10 4TG, UK.
Drug Discov Today. 2010 Feb;15(3-4):98-101. doi: 10.1016/j.drudis.2009.12.006. Epub 2010 Jan 4.
Molecular characterization of tumour material will become increasingly important in selecting patients for clinical trials and offering appropriate treatment for patients in clinical practice. Recent advances in the field have indicated that the molecular characteristics of a tumour can be determined from circulating tumour cells and circulating tumour DNA; thus, a simple blood sample could provide these data in a simple, convenient and efficient manner. This article discusses progress towards guiding treatment decisions through measuring tumour-derived factors in the circulation.
肿瘤组织的分子特征在选择临床试验患者和为临床患者提供适当治疗方面将变得越来越重要。该领域的最新进展表明，肿瘤的分子特征可以从循环肿瘤细胞和循环肿瘤 DNA 中确定；因此，简单的血液样本可以以简单、方便和有效的方式提供这些数据。本文讨论了通过测量循环中的肿瘤衍生因子来指导治疗决策的进展。
