人类支链酮酸脱氢酶复合体的二氢硫辛酰胺支链转酰酶基因（DBT）定位于1号染色体。
Localization of the dihydrolipoamide branched-chain transacylase gene (DBT) of the human branched-chain keto acid dehydrogenase complex to chromosome 1.
作者信息
Lau K S, Eddy R L, Shows T B, Fisher C W, Chuang D T, Cox R P
机构信息
Department of Biochemistry, University of Texas Southwestern Medical School, Dallas.
出版信息
Cytogenet Cell Genet. 1991;56(1):33-5. doi: 10.1159/000133041.
PMID:2004553
Abstract
The gene coding for the transacylase subunit (DBT) of the human branched-chain keto acid dehydrogenase complex was localized to chromosome 1 by probing panels of human x mouse chromosome hybrids with an E2 cDNA amplified by the polymerase chain reaction. Additional data with two hybrids containing chromosome 1 fragments suggest that the DBT gene is located on the short arm (1pter----p21) of the chromosome.
摘要
通过用聚合酶链反应扩增的E2 cDNA探测人x小鼠染色体杂种板，将人类支链酮酸脱氢酶复合体转酰酶亚基（DBT）的编码基因定位到1号染色体上。对两个含有1号染色体片段的杂种的进一步数据表明，DBT基因位于该染色体的短臂（1pter----p21）上。
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