具有第四代氟喹诺酮和中性双齿配体的四角锥形铜(II)配合物：结构、抗菌、SOD 模拟物和 DNA 相互作用研究。
Square pyramidal copper(II) complexes with forth generation fluoroquinolone and neutral bidentate ligand: structure, antibacterial, SOD mimic and DNA-interaction studies.
机构信息
Department of Chemistry, Sardar Patel University, Vallabh Vidyanagar 388 120, Gujarat, India.
出版信息
Bioorg Med Chem. 2010 Feb;18(3):1227-35. doi: 10.1016/j.bmc.2009.12.037. Epub 2009 Dec 22.
PMID:20045652
Abstract
Coordination of neutral bidentate ligand to copper ion in combination with gatifloxacin have been focused in this article. The effect of complexation reflects antibacterial activity, DNA interaction and SOD mimic activity of individual greatly. The geometry at the central metal ion provides a site for binding of superoxide anion responsible for better SOD mimic behaviour.
摘要
本文主要关注中性双齿配体与铜离子的配位。配合物的影响极大地反映了各个化合物的抗菌活性、DNA 相互作用和 SOD 模拟活性。中心金属离子的几何形状为超氧阴离子的结合提供了一个位点，这有助于更好地模拟 SOD 行为。
Zotero 插件