Xie Yiqun, Zeng Kaimin, Wang Yining, Xu Hongwei
Department of Geriatrics, Second Xiangya Hospital, Central South University, Changsha 410011, China.
Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2009 Dec;34(12):1166-70.
To investigate the association between transforming growth factor beta1(TGF-beta1)-800G>A polymorphism and cerebral infarction (CI).
The genotypes of 247 patients with atherosclerotic cerebral infarction and 167 sex- and age-matched healthy controls were detected by PCR-RFLP, and the frequency distribution of alleles calculated.
TGF-beta1-800G>A polymorphism was found in Han population in Hunan Province, China. The distribution of -800G>A genotypes was consistent with Hardy-Weinberg balance in the CI and healthy control group. There was no significant difference between genotypes and allele frequency of TGF-beta1-800G>A in the CI and control group (P>0.05). Logistic regression analysis suggested that no genotypes could increase or reduce the risk of CI onset (P>0.05).
TGF-beta1-800G>A polymorphism is not associated with CI in Han population in Hunan Province.
探讨转化生长因子β1（TGF-β1）-800G>A多态性与脑梗死（CI）之间的关联。
采用聚合酶链反应-限制性片段长度多态性（PCR-RFLP）技术检测247例动脉粥样硬化性脑梗死患者及167例性别、年龄匹配的健康对照者的基因型，并计算等位基因频率分布。
在中国湖南省汉族人群中发现了TGF-β1-800G>A多态性。-800G>A基因型在脑梗死组和健康对照组中的分布符合Hardy-Weinberg平衡。脑梗死组与对照组中TGF-β1-800G>A的基因型和等位基因频率无显著差异（P>0.05）。Logistic回归分析表明，各基因型均未增加或降低脑梗死发病风险（P>0.05）。
在湖南省汉族人群中，TGF-β1-800G>A多态性与脑梗死无关。
