[凝血因子 VII 激活蛋白酶的马尔堡 I 多态性与脑梗死]
[Marburg I polymorphism of Factor VII-activating protease and cerebral infarction].
作者信息
Tan Qian, Tang Huarong, Liu Rongrong, Wang Guangping, Yang Xiaosu, Chen Fangping
机构信息
Department of Hematology, Xiangya Hospital, Central South University, Changsha 410008, China.
出版信息
Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2009 Dec;34(12):1171-5.
OBJECTIVE
To determine the relation between Marburg I polymorphism of Factor VII-activating protease (FSAP) and cerebral infarction,and to analyze whether it is one of the risk factors of cerebral infarction.
METHODS
Single strand conformation polymorphism-polymerase chain reaction (SSCP-PCR) was applied for the polymorphism analysis of FSAP in 159 patients with cerebral infarction and 179 non-cerebral infarction subjects.
RESULTS
The phenotypes of FSAP in both the patients and the control subjects were wild type GG; no mutant of Marburg I was found. But a new gene mutation was tested, which had not been reported, requiring further investigation.
CONCLUSION
Marburg I polymorphism of FSAP may not be associated with cerebral infarction.
目的
确定凝血因子 VII 激活蛋白酶（FSAP）的马尔堡 I 多态性与脑梗死之间的关系，并分析其是否为脑梗死的危险因素之一。
方法
采用单链构象多态性 - 聚合酶链反应（SSCP-PCR）对159例脑梗死患者和179例非脑梗死受试者进行 FSAP 的多态性分析。
结果
患者和对照组中 FSAP 的表型均为野生型 GG；未发现马尔堡 I 的突变型。但检测到一个未报道过的新基因突变，需进一步研究。
结论
FSAP 的马尔堡 I 多态性可能与脑梗死无关。
Zotero 插件