Mai Xi, Lu Xiaosan, Xia Hongying, Cao Yusheng, Liao Yijing, Lv Xiaolan
State Key Laboratory of Food Science and Technology, Nanchang University, Nanchang, China.
Chem Pharm Bull (Tokyo). 2010 Jan;58(1):94-7. doi: 10.1248/cpb.58.94.
A series of hydroxyurea derivatives have been synthesized and elucidated by means of FT-IR, (1)H-, (13)C-NMR and MS. The exact stereostructures of representative compounds have been determined by X-ray crystal structure analysis. In the crystals, inversion dimers linked by pairs of N-H...O hydrogen bonds occurred, and further N-H...O links led to chains of molecules. In vitro antitumor activities against Tca8113 human tongue cancer cells and L1210 murine leukemia cells were evaluated. A total of 8 of the 12 compounds had higher inhibitory activities than hydroxyurea against L1210 cells. Among them, the most promising compounds were 3e, 3d, 3a and 2d.
