Son Jun Seong, Lee Mi Suk, Kang So Young, Lee Woo In
Department of Internal Medicine, Kyunghee University College of Medicine, Seoul, Korea.
Korean J Lab Med. 2009 Dec;29(6):551-6. doi: 10.3343/kjlm.2009.29.6.551.
Healthcare workers (HCW) are known as a risk group of hepatitis A virus (HAV) infection and vaccination of this group against HAV has been suggested. However, the seroprevalence of HAV antibody among HCW in Korea has not been reported. We investigated the seropositivity of HAV antibody in HCW, to obtain a baseline data.
We measured serum total HAV antibody using chemiluminescent immunoassay (ADVIA Centaur, Germany) in 174 HCW at one university hospital in Seoul, Korea.
Serum HAV antibody was positive in 48 (27.6%) of 174 subjects tested. The seropositivity of HAV antibody was significantly increased with increasing age: 21.1% (26/123), 55% (22/40), and 100% (11/11) in the age groups of 20's, 30's, and 40's, respectively (P<0.001). However it was not significantly different among different occupations (physicians 38%, nurses 24.6%, other workers 31.4%, P=0.376) and work places (medical ward 29.1%, pediatric ward 25.9%, emergency room 34.4%, laboratory 0%, P=0.140). The seroprevalence rate of HAV antibody in the age groups of 20's and 30's in this study was not higher than that of previous studies on non-HCW populations in Korea since 2006.
The seroprevalence of HAV antibody among HCW in the age groups of 20's and 30's in a Korean hospital was not higher than that of non-HCW populations, and the seropositivity increased with increasing age. Further studies are needed for the age-specific strategy for vaccination, considering the increased risk of exposure in HCW to HAV infection in hospital environment with the increase of symptomatic patients with HAV.
医护人员被认为是甲型肝炎病毒（HAV）感染的风险群体，有人建议对该群体进行HAV疫苗接种。然而，韩国医护人员中HAV抗体的血清流行率尚未见报道。我们调查了医护人员中HAV抗体的血清阳性率，以获取基线数据。
我们在韩国首尔的一家大学医院，使用化学发光免疫分析法（德国西门子ADVIA Centaur）对174名医护人员检测血清总HAV抗体。
在174名检测对象中，48人（27.6%）血清HAV抗体呈阳性。HAV抗体的血清阳性率随年龄增长显著升高：20多岁年龄组为21.1%（26/123），30多岁年龄组为55%（22/40），40多岁年龄组为100%（11/11）（P<0.001）。然而，不同职业（医生38%，护士24.6%，其他工作人员31.4%，P=0.376）和工作场所（内科病房29.1%，儿科病房25.9%，急诊室34.4%，实验室0%，P=0.140）之间无显著差异。本研究中20多岁和30多岁年龄组的HAV抗体血清流行率不高于2006年以来韩国非医护人员群体的既往研究结果。
韩国一家医院20多岁和30多岁年龄组医护人员中HAV抗体的血清流行率不高于非医护人员群体，且血清阳性率随年龄增长而升高。考虑到随着甲型肝炎症状性患者增加，医护人员在医院环境中接触HAV感染的风险增加，需要针对不同年龄制定疫苗接种策略，进一步开展研究。
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