Rocchietti March M, Pisani D, Aliberti G
Department of Internal Medicine, Sant'Andrea Hospital, Rome, Italy.
Minerva Endocrinol. 2009 Dec;34(4):325-32.
Osteoporosis is a worldwide major public health problem, defined as "a systemic skeletal disease characterized by low bone mass and microarchitectural deterioration of bone tissue with a consequent increase in bone fragility and susceptibility to fractures". Osteoporosis is diagnosed by bone mineral density measurement (T-score of -2.5 or below) also in men. However, most of the studies carried out in the last decade focused on pathogenesis, diagnosis and treatment of osteoporosis in women. In spite of this, recent epidemiological and observational studies have shown that osteoporosis in men is an increasingly important clinical issue. In part because the world population is aging, it is likely that the total number of hip fractures in men in 2025 will be similar to current estimates in women. Furthermore 25-33% of men in some populations will sustain osteoporotic fractures in their lifetime. Nevertheless, male osteoporosis is still underdiagnosed and further studies are required to clarify the pathogenesis and find out the right therapy. Prevention and early diagnosis are, nowadays, the best ways of treatment.
骨质疏松症是一个全球性的重大公共卫生问题，被定义为“一种全身性骨骼疾病，其特征为骨量低和骨组织微结构退化，进而导致骨脆性增加和骨折易感性增加”。男性也可通过骨密度测量（T值小于或等于 -2.5）来诊断骨质疏松症。然而，过去十年开展的大多数研究都集中在女性骨质疏松症的发病机制、诊断和治疗上。尽管如此，最近的流行病学和观察性研究表明，男性骨质疏松症正成为一个日益重要的临床问题。部分原因是世界人口老龄化，预计到2025年男性髋部骨折的总数将与目前女性的估计数相近。此外，在某些人群中，25%至33%的男性一生中会发生骨质疏松性骨折。尽管如此，男性骨质疏松症仍未得到充分诊断，需要进一步研究以阐明其发病机制并找到合适的治疗方法。如今，预防和早期诊断是最佳的治疗方式。
